{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:11:14Z","timestamp":1790604674202,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this study is to evaluate salvage treatment after primary radiation therapy (RT) for prostate cancer within our hospital system. Specifically, we aim to evaluate treatment patterns, oncologic outcomes and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We retrospectively identified men with post\u2010RT recurrence treated with salvage radical prostatectomy (sRP), seminal vesiculectomy, cryoablation, high\u2010dose\u2010rate brachytherapy (HDR) or irreversible electroporation (IRE). Salvage failure was defined as biochemical recurrence (BCR; Phoenix criteria, nadir\u2009+\u20092\u2009ng\/mL for cryoablation, HDR and IRE or prostate\u2010specific antigen (PSA)\u2009&gt;\u20090.2\u2009ng\/mL for sRP and seminal vesiculectomy) or need for subsequent therapy. Cox regression identified factors associated with time to failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010one patients underwent salvage therapy after RT; 58 (81.7%) cryoablation, 7 (9.9%) sRP, 2 (2.8%) robotic seminal vesiculectomies, and 4 (5.6%) other modalities. Failure occurred in 30 (45%) patients at a median of 12.5\u2009months (IQR 6, 23). Grade group (GG) 4\u20135 disease prior to RT was associated with time to failure (HR 2.18, 95% CI 0.96, 4.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.063) on multivariable analysis; however, the difference was not significant. Treatment type was not significantly associated with failure\u2010free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.7). Four patients experienced Clavien\u2013Dindo grade III or higher complications: three following sRP (two anastomosis dehiscence, clot retention) and one following cryoablation (stricture). Ten patients (14%) underwent local salvage for prostate recurrences in the setting of N1\/M1 disease with concurrent systemic therapy, with no treatment escalation or complications at median 16\u2009months follow\u2010up time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this institutional cohort, salvage cryoablation demonstrated an acceptable short\u2010term failure\u2010free survival with fewer observed high\u2010grade complications than salvage prostatectomy. Salvage cryoablation also appeared feasible in select patients with low\u2010volume nodal or metastatic disease. These findings are hypothesis\u2010generating and require prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70259","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:14:14Z","timestamp":1787890454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salvage prostate therapies for local pelvic recurrence after primary radiation for prostate cancer"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6214-1568","authenticated-orcid":false,"given":"Jamie","family":"Michael","sequence":"first","affiliation":[{"name":"Department of Urology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2621-815X","authenticated-orcid":false,"given":"Kathryn","family":"Fink","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Urology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai K. 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R.","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Preventative Medicine, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton","family":"Neill","sequence":"additional","affiliation":[{"name":"Department of Urology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-9596","authenticated-orcid":false,"given":"Ridwan","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Urology, Feinberg School of Medicine Northwestern University  Chicago Illinois 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