{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:11:49Z","timestamp":1790604709048,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008730","name":"Kreftforeningen","doi-asserted-by":"publisher","award":["198016\u20102018"],"award-info":[{"award-number":["198016\u20102018"]}],"id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to determine the feasibility and safety of administering perioperative propranolol, as an adjunct to reduce prostate cancer recurrence, in patients undergoing robotic\u2010assisted laparoscopic prostatectomy (RALP) for European Association of Urology (EAU) intermediate\u2010 or high\u2010risk prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Treatment\u2010na\u00efve men aged 40\u201380\u2009years with EAU intermediate\u2010 or high\u2010risk prostate cancer scheduled for RALP were enrolled in this single\u2010centre, randomised, double\u2010blind, placebo\u2010controlled, phase 2 pilot trial. Participants were randomised 1:1 to receive propranolol or placebo for approximately 3\u2009weeks (about 1\u2009week pre\u2010RALP and 2\u2009weeks post\u2010RALP). Serial blood sampling was performed to measure catecholamine metabolites, serum propranolol and short\u2010interval prostate\u2010specific antigen (PSA) dynamics. Participants self\u2010monitored pulse rate and blood pressure twice daily.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over 36\u2009weeks in 2023, 160 patients underwent RALP; 111 were prescreened, 49 were fully screened and 40 were randomised, corresponding to inclusion rates of 36% among prescreened and 82% among fully screened patients. Pre\u2010RALP adherence was 98% in both arms; post\u2010RALP adherence was lower in the propranolol arm. No Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 grade \u22653 adverse events were attributed to propranolol, and no surgeries were delayed. The epinephrine metabolite metanephrine increased intraoperatively in both arms and declined by the end of treatment. Mean preoperative PSA decreased more with propranolol than with placebo. As this pilot was not powered to detect between\u2010group differences, such differences are hypothesis\u2010generating only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PeP\u2010RALP demonstrated that perioperative propranolol is operationally feasible and demonstrated an acceptable safety profile within RALP workflows, with strong preoperative adherence. Our study supports a multicentre efficacy randomised controlled trial with standardised anaesthetic protocols, postoperative adherence support and oncological endpoints. All physiological and molecular results, including PSA dynamics, in this pilot are exploratory and solely intended to inform the design of any future trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70267","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:08:31Z","timestamp":1787807311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative propranolol during robotic\u2010assisted radical prostatectomy: A randomised, double\u2010blind, placebo\u2010controlled, pilot trial (PeP\u2010RALP)"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2089-2248","authenticated-orcid":false,"given":"Shivanthe","family":"Sivanesan","sequence":"first","affiliation":[{"name":"Department of Cancer Surgery The Norwegian Radium Hospital, Oslo University Hospital  Oslo Norway"},{"name":"Department of Tumor Biology, Institute of Cancer Research Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kon","family":"Ramberg","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology, Institute of Cancer Research Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department Anaesthesia, Operations and Intensive Care The Norwegian Radium Hospital, Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj B.","family":"Thapa","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Division of Mental Health and Addiction Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marthe","family":"Bj\u00f8re","sequence":"additional","affiliation":[{"name":"Department of Cancer Surgery The Norwegian Radium Hospital, Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Berge","sequence":"additional","affiliation":[{"name":"Department of Cancer Surgery The Norwegian Radium Hospital, Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Ottosson","sequence":"additional","affiliation":[{"name":"Department of Cancer Surgery The Norwegian Radium Hospital, Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Brennhovd","sequence":"additional","affiliation":[{"name":"Department of Cancer Surgery The Norwegian Radium Hospital, Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-9163","authenticated-orcid":false,"given":"Anne M. H.","family":"Stor\u00e5s","sequence":"additional","affiliation":[{"name":"Department of Oncology The Norwegian Radium Hospital, Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per M.","family":"Thorsby","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Hormone Laboratory, Department of Medical Biochemistry and Endocrinology and Metabolism Research Group Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra R.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Hormone Laboratory, Department of Medical Biochemistry and Endocrinology and Metabolism Research Group Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Urbanucci","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology, Institute of Cancer Research Oslo University Hospital  Oslo Norway"},{"name":"Center for Cancer Eradication Research, Faculty of Medicine and Health Technology Tampere University and TAYS Cancer Center, Tampere University Hospital  Tampere Finland"},{"name":"Finnish Cancer Institute  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene Hartvedt","family":"Grytli","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology, Institute of Cancer Research Oslo University Hospital  Oslo Norway"},{"name":"Norsk legemiddelh\u00e5ndbok  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bjerke","sequence":"additional","affiliation":[{"name":"Prostatakreftforeningen (PROFO)  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-4915","authenticated-orcid":false,"given":"Kristin Austlid","family":"Task\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology, Institute of Cancer Research Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01282-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.194"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31594"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.224"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.1.109"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501677"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.05.014"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1447"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb5817"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32950"},{"key":"e_1_2_11_12_1","article-title":"Pre\u2010operative \u03b2\u2010blockade with propranolol reduces biomarkers of metastasis in breast cancer: a phase II randomized trial","author":"Hiller JG","year":"2019","journal-title":"Clin. 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