{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:53:37Z","timestamp":1791424417036,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This work aimed to evaluate the efficacy and safety of Aquablation for the treatment of benign prostatic enlargement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted in accordance with PRISMA 2020 guidelines (PROSPERO CRD420261401865). A comprehensive PubMed search identified prospective studies and randomised controlled trials published up to January 2026. Studies including \u226530 patients reporting clinical outcomes of Aquablation were included. Guidelines, case reports, review articles, letters, retrospective studies with pooled data were excluded. Primary outcomes were International Prostate Symptom Score, maximum flow rate, postvoid residual and sexual function. Secondary outcomes included perioperative parameters and complications. Random\u2010effects meta\u2010analysis using DerSimonian\u2013Laird was performed for outcomes reported in three or more studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen studies comprising 1580 patients were included. Mean age and prostate volume were 67.0\u00a0years and 82.1\u00a0cc, respectively. Aquablation significantly improved urinary outcomes, with a pooled IPSS reduction of \u221215.80 at 6\u00a0months (95% confidence interval [CI] \u221217.88 to \u221213.73;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u200997.8%), sustained to 36\u2009months.\n                      <jats:italic>Q<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      increased by 11.0\u00a0mL\/s (95% CI 8.93\u201313.02;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u200995.1%), while PVR decreased by 103.8\u00a0mL (95% CI \u2212139.5 to \u221268.0;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u200998.1%) at 6\u00a0months. Ejaculatory dysfunction occurred in 7.4% of patients, with no reported erectile dysfunction. The transfusion rate was 2.5%, with lower rates observed using focal bladder neck cautery. Most complications were low grade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aquablation provides durable and significant improvements in urinary outcomes with a favourable safety profile and low rates of sexual dysfunction, supporting its role as an effective surgical option for BPE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70292","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:45:29Z","timestamp":1791423929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A systematic review and meta\u2010analysis on the safety and efficacy of Aquablation"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2320-5696","authenticated-orcid":false,"given":"Kimberley","family":"Chan","sequence":"first","affiliation":[{"name":"Hertfordshire and Bedfordshire Urological Cancer Centre, Department of Urology Lister Hospital, East and North Hertfordshire NHS Teaching Trust  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8698-6461","authenticated-orcid":false,"given":"Nico Christian","family":"Grossmann","sequence":"additional","affiliation":[{"name":"Clinic for Urology University Teaching and Research Hospital of the University of Lucerne  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2135-3169","authenticated-orcid":false,"given":"Matthew","family":"Feyissa","sequence":"additional","affiliation":[{"name":"Hertfordshire and Bedfordshire Urological Cancer Centre, Department of Urology Lister Hospital, East and North Hertfordshire NHS Teaching Trust  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Nettleton","sequence":"additional","affiliation":[{"name":"Cheltenham General Hospital, Gloucestershire Hospitals NHS Foundation Trust  Cheltenham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7775-2812","authenticated-orcid":false,"given":"Philip","family":"Charlesworth","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Urology Frimley Park Hospital  London 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