{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:29:48Z","timestamp":1783574988468,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a decade of our experience with a neo\u2010urethral modification of ileal orthotopic neobladder (pitcher pot ONB). Multiple investigators have reported similar modifications. However, long\u2010term longitudinal functional and quality of life (QOL) outcomes are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospectively maintained hospital registry for 238 ONB patients comprising a mix of open and robotic surgery cohorts from 2007 to 2017, and minimum of 2\u00a0years of follow\u2010up was retrospectively queried. QOL was evaluated using Bladder Cancer Index (BCI). Longitudinal trends of QOL domain parameters were analysed. List of perioperative variables that have a biologically plausible association with continence, potency, and post\u2010operative BCI QOL sexual, urinary, and bowel domain scores was drawn. Variables included surgery type, Body Mass Index (BMI), T and N stage, neurovascular bundle (NVB) sparing, age, and related pre\u2010operative BCI QOL domain score. Prognostic associations were analysed using multivariable Cox proportional hazard models and multilevel mixed\u2010effects modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study comprised 80 and 158 patients who underwent open and robotic sandwich technique cohorts, respectively. Open surgery was associated with significantly higher \u201cany\u201d complication (40% vs 27%, <jats:italic>P<\/jats:italic>\u2010value .050) and \u201cmajor\u201d complication rate (15% vs 11%, <jats:italic>P<\/jats:italic>\u2010value .048). All patients developed a bladder capacity\u00a0&gt;400\u00a0cc with negligible post\u2010void residual urine, and all but one patient achieved spontaneous voiding by the end of study period (&lt;1% clean intermittent self\u2010catheterization [CISC] rate). By 15\u00a0months, QOL for all three domains had recovered to reach a plateau. About 45% of patients achieved potency, and the median time to achieve day and night time continence was 9 and 12\u00a0months respectively. Lower age and NVBs spared during surgery were found to be significantly associated with the earlier achievement of potency, day and night time continence, as well as better urinary and sexual summary QOL scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pitcher pot neobladder achieves satisfactory long\u2010term functional and QOL outcomes with negligible CISC rate. Results were superior with incremental nerves spared during surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bco2.82","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T10:47:46Z","timestamp":1622803666000},"page":"292-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pitcher pot neourethral modification of ileal orthotopic neobladder achieves satisfactory long\u2010term functional and quality of life outcomes with low clean intermittent self\u2010catheterization rate"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3223-8155","authenticated-orcid":false,"given":"Jiten","family":"Jaipuria","sequence":"first","affiliation":[{"name":"Amity Centre for Cancer Epidemiology &amp; Cancer Research Amity Institute of Biotechnology Amity University Uttar Pradesh  Noida India"},{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Mamoon","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8180-1891","authenticated-orcid":false,"given":"Amitabh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash Bikram","family":"Thapa","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashikant","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nripesh","family":"Sadasukhi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikandan","family":"Venkatasubramaniyan","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyatham","family":"Kasaraneni","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9114-6739","authenticated-orcid":false,"given":"Ashish","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar Aditya","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-5700","authenticated-orcid":false,"given":"Girish","family":"Sharma","sequence":"additional","affiliation":[{"name":"Centre for Medical Biotechnology, Coordinator Amity Centre for Cancer Epidemiology &amp; Cancer Research Amity Institute of Biotechnology Amity University Uttar Pradesh  Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-2372","authenticated-orcid":false,"given":"Sudhir","family":"Rawal","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Uro\u2010oncology Division Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2484-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.04641.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyl100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn079"},{"key":"e_1_2_11_7_1","unstructured":"NCCN guidelines: Bladder cancer. 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