{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:39:35Z","timestamp":1780411175168,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Various factors can impair wound healing by disrupting key stages of the process. This study evaluates the impact of concomitant anticoagulant medication on wound healing in a cohort of 212 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data from 2 open\u2010label, blindly evaluated, prospective, randomized, multicentre phase III trials (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u00a0212) were analysed. Healing durations of patients taking anticoagulants were compared to a control group (split\u2010thickness skin graft donor site halves treated with standard moist wound dressing). Kaplan\u2013Meier estimators and multivariable Cox regression were applied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Kaplan\u2013Meier analysis demonstrated significantly accelerated wound healing in patients treated with enoxaparin or nadroparin. Among monotherapies, 75% of patients on enoxaparin achieved wound closure within 16.5\u00a0days (95% confidence interval [CI]: 14\u201321), and those on nadroparin within 15\u2009days (95% CI: 11.5\u201319), compared to 24\u2009days (95% CI: 20\u201328) in patients receiving other anticoagulants (log\u2010rank test:\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u2009.001). Cox regression confirmed a significantly faster healing rate with enoxaparin or nadroparin (hazard ratio\u2009=\u00a01.50, 95% CI: 1.02\u20132.19,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u2009.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Enoxaparin and nadroparin may enhance wound healing, whereas phenprocoumon, acetylsalicylic acid, and certain low\u2010molecular\u2010weight heparins (certoparin, tinzaparin, dalteparin, bemiparin) appear to delay wound healing. Anticoagulant monotherapy with enoxaparin or nadroparin should be considered postoperatively when feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70073","type":"journal-article","created":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T23:34:31Z","timestamp":1745796871000},"page":"2583-2589","source":"Crossref","is-referenced-by-count":2,"title":["Influence of anticoagulant concomitant medication on wound healing: Analysis of a multicentre cohort of 212 patients with a uniform wound model"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-6824","authenticated-orcid":false,"given":"Christian","family":"Seebauer","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Plastic Surgery University Medicine L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fares","family":"Hanafieh","sequence":"additional","affiliation":[{"name":"Department of 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