{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:03:47Z","timestamp":1790309027598,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Gene polymorphisms play a critical role in the variability of plasma concentrations of direct\u2010acting oral anticoagulants (DOACs). In this study, we aimed to investigate the effects of genetic variants on the clinical outcomes of Chinese patients treated with DOACs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The retrospective study recruited 720 patients with nonvalvular atrial fibrillation who were receiving dabigatran, rivaroxaban or edoxaban. Cox regression models were employed to compare the clinical outcomes between carriers and noncarriers of the key single nucleotide polymorphisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Results revealed that the\n                      <jats:italic>CES1<\/jats:italic>\n                      rs2244613 C allele significantly reduced bleeding events in patients treated with dabigatran (adjusted hazard ratio 0.33, 95% confidence interval 0.13\u20130.85,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u2009.021). The carriage of\n                      <jats:italic>ABCB1<\/jats:italic>\n                      rs1045642 T allele was associated with a lower risk of thromboembolism in rivaroxaban users (adjusted hazard ratio 0.19, 95% confidence interval 0.07\u20130.57,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u2009.003). Additionally, a trend toward statistical significance (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u2009.052) was observed between the\n                      <jats:italic>SLCO1B1<\/jats:italic>\n                      rs4149056 C allele and bleeding risk among the edoxaban users.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study showed that the\n                      <jats:italic>CES1<\/jats:italic>\n                      rs2244613 and\n                      <jats:italic>ABCB1<\/jats:italic>\n                      rs1045642 alleles were associated with outcome events in Chinese patients taking dabigatran and rivaroxaban, respectively. The findings could help predict clinical outcomes and develop personalized anticoagulation treatment strategies for Chinese patients taking DOACs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70078","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:19:00Z","timestamp":1747873140000},"page":"2736-2744","source":"Crossref","is-referenced-by-count":4,"title":["Relevance of selected pharmacogenetic polymorphisms to bleeding and thromboembolic risks in Chinese patients taking direct\u2010acting oral anticoagulants"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5189-0348","authenticated-orcid":false,"given":"Dongxu","family":"Wang","sequence":"first","affiliation":[{"name":"Cardiovascular Department Beijing Hospital, National Center of Gerontology  Beijing China"},{"name":"Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"An","sequence":"additional","affiliation":[{"name":"Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaru","family":"Chai","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Huo","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrong","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Du","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Dai","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Geriatrics Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm9010007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(24)00281\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056355"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.020232"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13844"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003283"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.05.025"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/17539447241249886"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001233"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959\u2010018\u20100183\u20103"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14646"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2016.82"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13577"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2714"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010024\u201001358\u20103"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1007113"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm10030133"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557\u2010023\u201007495\u20104"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.000990"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101718729"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002927"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2005.01204.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13140"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16182"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2022.01278"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2316"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201043179\u20107"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002968"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010020\u201001509\u2010x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad200"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010022\u201002910\u20104"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.959916"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S291723"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60101712"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666181018153641"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000178311.02878.83"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2024.020703"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500413"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.054866"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001042"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1263"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bcp.70078","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T06:33:23Z","timestamp":1775630003000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/bcp.70078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/bcp.70078"],"URL":"https:\/\/doi.org\/10.1002\/bcp.70078","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]}}}