{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:07:44Z","timestamp":1775632064229,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0016\/0020"],"award-info":[{"award-number":["RD21\/0016\/0020"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to identify patterns of direct oral anticoagulant (DOAC) and vitamin K antagonist (VKA) use in hospitalized patients and to examine their association with in\u2010hospital haemorrhagic complications and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational cross\u2010sectional study was conducted among hospitalized patients \u226518\u2009years from 2018 to 2022. Data on hospital discharges were obtained from the minimum data set and were matched with pharmacy records to identify patients treated with DOACs or VKAs. In\u2010hospital haemorrhagic complications and mortality rates were calculated for study groups. Multivariate logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95%CIs), adjusting for age, sex and comorbidities. Analyses were stratified by medical and surgical profiles. Statistical significance was set at .05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 74\u2009190 patients, with 4774 receiving DOACs and 1768 VKAs. During the study period, DOAC use increased by 45.11%. DOAC\u2010treated patients had lower complication rates than those treated with VKAs (1.9\n                      <jats:italic>vs<\/jats:italic>\n                      . 2.8%, respectively;\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u2009.032). DOAC use was linked to a lower risk of haemorrhagic complications in surgical patients (OR\u2009=\u20090.65; 95%CI: 0.35\u20130.91), while in medical patients, the reduction in risk was not statistically significant (OR\u2009=\u20090.59; 95%CI: 0.33\u20131.10). No effect on mortality risk was observed among medical and surgical patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The increased use of DOACs among hospitalized patients showed a protective effect against haemorrhagic complications in surgical patients, supporting their increasing use in hospital settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70087","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T05:41:13Z","timestamp":1746596473000},"page":"2649-2658","source":"Crossref","is-referenced-by-count":0,"title":["Association between oral anticoagulant therapy and in\u2010hospital complications and mortality"],"prefix":"10.1002","volume":"91","author":[{"given":"Juliana","family":"Lagrave","sequence":"first","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Epidemiology and Evaluation Hospital del Mar  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-0891","authenticated-orcid":false,"given":"Laia","family":"Domingo","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Epidemiology and Evaluation Hospital del Mar  Barcelona Spain"},{"name":"RICAPPS. 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Research Network on Chronicity, Primary Care, and Prevention and Health Promotion, Carlos III Health Institute  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Sala","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Epidemiology and Evaluation Hospital del Mar  Barcelona Spain"},{"name":"RICAPPS. Research Network on Chronicity, Primary Care, and Prevention and Health Promotion, Carlos III Health Institute  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","unstructured":"ColacciM TsengEK SacksCA FralickM.Oral anticoagulant utilization in the United States and United Kingdom. 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