{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:59Z","timestamp":1786977119646,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    Weight gain and metabolic disruptions are common in children and adolescents treated with antipsychotics, but the underlying mechanisms are unclear, complicating prevention and treatment. This study examines the impact of risperidone on appetite\u2010regulating hormones (insulin, leptin and bioleptin) and their relationship to body weight changes over time. In a post hoc analysis, we evaluated the correlation of appetite\u2010regulating hormones with BMI z\u2010scores during treatment and at a 6\u2010month follow\u2010up. The sample consisted of 10 participants (80% male, median age 9.7\u00a0years). A significant increase in bioleptin (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.05) and BMI z\u2010scores was observed over the 6 month period. At baseline, HOMA\u2010IR, insulin, leptin, and bioleptin were significantly correlated with the BMI z\u2010score; however, these associations were no longer observed after 6 months of treatment. Additionally, higher risperidone exposure correlated with lower appetite\u2010regulating hormone levels\u00a0at the 6\u2010month mark. These findings indicate that risperidone significantly affects appetite\u2010regulating hormones in children and adolescents, potentially contributing to antipsychotic\u2010induced weight gain.\n                  <\/jats:p>","DOI":"10.1002\/bcp.70095","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:35:55Z","timestamp":1747726555000},"page":"2090-2094","source":"Crossref","is-referenced-by-count":1,"title":["Alterations of appetite\u2010regulating hormones in risperidone treated children and adolescents\u2014a post hoc analysis of the SPACe study"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5796-3412","authenticated-orcid":false,"given":"Jiayi","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Hospital Pharmacy Maasstad Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-8443","authenticated-orcid":false,"given":"Brenda C. M.","family":"de Winter","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-2246","authenticated-orcid":false,"given":"Rebecca A.","family":"Hermans","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2573-4636","authenticated-orcid":false,"given":"Sanne M.","family":"Kloosterboer","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Kuckuck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology Erasmus MC  Rotterdam The Netherlands"},{"name":"Obesity Center CGG Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izgi","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth F. C.","family":"van Rossum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology Erasmus MC  Rotterdam The Netherlands"},{"name":"Obesity Center CGG Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon H. J.","family":"Hillegers","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-7505","authenticated-orcid":false,"given":"Sander A. A.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-3643","authenticated-orcid":false,"given":"Birgit C. P.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Dierckx","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S151802"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787\u2010013\u20100399\u20105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.032"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13539"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.21m14110"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2017.02.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14465"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000411"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010019\u20101220\u20108"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T03:49:28Z","timestamp":1764560968000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/bcp.70095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/bcp.70095"],"URL":"https:\/\/doi.org\/10.1002\/bcp.70095","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]}}}