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We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions of metamizole. Metamizole has a fast analgesic effect but a short half\u2010life and duration of action. The exact mechanism of action of metamizole is currently not fully known. Studies showed that metamizole appears to be a moderate to strong inductor of the enzymes CYP3A4, CYP2B6 and CYP2C19; a weak inductor of CYP2C9; and a moderate inhibitor of CYP1A2. Furthermore, metamizole inhibits the effect of acetylsalicylic acid when taken simultaneously. Metamizole should be cautiously used together with other drugs that can cause agranulocytosis. 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