{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:11:06Z","timestamp":1758874266746,"version":"3.44.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>In studies requiring repeated blood sampling, a cannula is typically inserted into a peripheral vein and used for regular blood draws. In some studies, subtherapeutic doses of heparin is infused overnight to maintain cannula patency; however, there is limited evidence supporting its use in this context. Normal saline infusions have been proposed as an alternative for extending cannula lifespan. This study aims to address the clinical need for data on blood collection techniques in healthy participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted at the Surrey Clinical Research Facility (CRF)\/Surrey Sleep Research Centre (SSRC) sleep laboratory, involved five healthy males and females aged 18\u201335\u2009years receiving a 6\u2010h normal saline infusion. The primary outcome included the difficulty of drawing blood at hourly intervals, the incidence of phlebitis, re\u2010cannulation and adverse events, as well as the condition of the cannulas post\u2010infusion, assessed during each hourly blood draw.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By the fourth interval, 80% of blood draws were made with no difficulty, reducing to 40% by the end of the study. Self\u2010limiting discomfort (score of 1 on VIP scale) was observed in two participant's cannulas; this resolved quickly in both cases. All five cannulas remained patent throughout and after the 6\u2010h normal saline infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While normal saline shows promise in maintaining peripheral cannula patency, a double\u2010blinded clinical trial with a larger sample size is necessary to establish statistical significance in the comparison of heparin and normal saline.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bcp.70123","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T19:19:01Z","timestamp":1748805541000},"page":"2902-2909","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the feasibility of infusing slow normal saline through a three\u2010metre\u2010longline to maintain patency of a peripheral venous cannula: A pilot study"],"prefix":"10.1002","volume":"91","author":[{"given":"Anaelle","family":"Lubila","sequence":"first","affiliation":[{"name":"University of Surrey, Clinical Research Facility, Surrey Clinical Research Building  Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-8110","authenticated-orcid":false,"given":"Matthew","family":"Parsons","sequence":"additional","affiliation":[{"name":"University of Surrey, Clinical Research Facility, Surrey Clinical Research Building  Guildford UK"},{"name":"NIHR Royal Surrey CRF, Royal Surrey NHS Foundation Trust  Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris Wood","family":"Campar","sequence":"additional","affiliation":[{"name":"University of Surrey, Clinical Research Facility, Surrey Clinical Research Building  Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Hassanin","sequence":"additional","affiliation":[{"name":"University of Surrey, Clinical Research Facility, Surrey Clinical Research Building  Guildford UK"},{"name":"NIHR Royal Surrey CRF, Royal Surrey NHS Foundation Trust  Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colegn.2019.07.010"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201021617\u20101"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.1990.13.s6.12"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884217503255203"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741\u20106787.2012.00244.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000183"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007364.pub2"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010016\u20101585\u2010x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060516685203"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/10760296990050S103"},{"key":"e_1_2_13_12_1","first-page":"107","volume-title":"Factors affecting drug metabolism: internal factors","author":"Gibson GG","year":"1996"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2019.v109i11.14442"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu005"},{"volume-title":"Visual infusion phlebitis score","year":"1997","author":"Jackson A","key":"e_1_2_13_15_1"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:31:19Z","timestamp":1758871879000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/bcp.70123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/bcp.70123"],"URL":"https:\/\/doi.org\/10.1002\/bcp.70123","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"type":"print","value":"0306-5251"},{"type":"electronic","value":"1365-2125"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}