{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:35:42Z","timestamp":1791318942129,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Breast milk is the optimal infant nutrition; however, many infants may be exposed to prescription drugs if used by their mothers during breastfeeding. The aim of this study was to evaluate the prevalence and patterns of prescription drug use among breastfeeding mothers and to assess the availability of relative infant dose information for these drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This population\u2010based cohort study was conducted using nationwide Danish register data from January 2006 to December 2022. All registered mother\u2013infant pairs were included during periods of exclusive breastfeeding. The national health registers were used to identify live births, breastfeeding status and prescription drug use by mothers during exclusive breastfeeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 534\u2009080 exclusively breastfed infants, 290\u2009845 (54.5%) were breastfed by mothers who used at least 1 prescription drug during the breastfeeding period. The drugs were primarily for haemorrhoids, contraception, infections and pain management. Among individual systemic drugs used during exclusive breastfeeding, 51.5% lacked information on relative infant dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This large\u2010scale cohort study reveals a high prevalence of prescription drug use during exclusive breastfeeding, often involving drugs with unknown safety profiles regarding their transfer into human milk. These findings highlight the need for updated regulatory measures and increased efforts by pharmaceutical companies to ensure reliable infant safety data.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bcp.70139","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:38:09Z","timestamp":1749793089000},"page":"2979-2987","source":"Crossref","is-referenced-by-count":9,"title":["Prescription drug use in breastfeeding mothers and infant exposure: A register\u2010based cohort study"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-5726","authenticated-orcid":false,"given":"Ditte Resendal","family":"Gotfredsen","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg, Copenhagen  Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6130-875X","authenticated-orcid":false,"given":"Ida M.","family":"Heerfordt","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg, Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Storm Baden","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg, Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg, Copenhagen  Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-6158","authenticated-orcid":false,"given":"Christina","family":"Gade","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg, Copenhagen  Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon Tr\u00e6rup","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg, Copenhagen  Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022\u2010057988"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)01024\u20107"},{"key":"e_1_2_11_4_1","unstructured":"Sundhedsstyrelsen The Danish Health Authority.The National Child Database \u2010 Danish Health Data Authority. 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