{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:48:49Z","timestamp":1761742129928,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Botulinum toxin type A (BoNT\u2010A) is widely used for its efficacy in treating a variety of neuromuscular disorders. However, data on its safety and adverse events (AEs) in real\u2010world settings remain limited. The Food and Drug Administration Adverse Event Reporting System (FAERS) database provides an invaluable resource for evaluating the safety of BoNT\u2010A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used four methods to evaluate the disproportionality of AEs associated with BoNT\u2010A: the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the multi\u2010item gamma Poisson shrinker (MGPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 17\u2009307\u2009196 case reports in the FAERS database, there were 69\u2009644 reports where BoNT\u2010A was listed as the \u201cprimary suspect\u201d for AEs. BoNT\u2010A\u2010related AEs affected 27 system organ classes (SOCs). Based on the four algorithms, 290 significant disproportionalities at the Preferred Term (PT) level were retained. Unexpected AEs, such as skin wrinkles, hyperacusis, Guillain\u2010Barr\u00e9 syndrome, mediastinitis and infective aneurysm, were identified, which are not mentioned in the product insert.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides an overview of AEs in the real\u2010world use of BoNT\u2010A, revealing its broad safety profile. Although the majority of AEs were mild to moderate, there is a need to remain vigilant for serious AEs and to monitor them in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70141","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T21:39:25Z","timestamp":1751492365000},"page":"3104-3113","source":"Crossref","is-referenced-by-count":0,"title":["A study on adverse events of botulinum toxin type A in real\u2010world applications: A FAERS database analysis"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-8080","authenticated-orcid":false,"given":"Weizhen","family":"He","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Provincial Hospital of Fuzhou University  Fu Zhou Fujian China"},{"name":"Department of Neurosurgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen Fujian China"},{"name":"Xiamen Medical Quality Control Center for Neurosurgery  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Xiang'an Hospital of Xiamen University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Xiang'an Hospital of Xiamen University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xiang'an Hospital of Xiamen 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