{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:48:41Z","timestamp":1761742121515,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Polypharmacy is common in adult patients with inflammatory bowel disease (IBD). This study aims to quantify medication prescriptions and estimate the risk of polypharmacy over time in older adults with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a nationwide cohort of adult incident IBD patients from 1 April 1996, to 31 December 2019, we examined medication prescriptions across calendar years among young adults (18\u201339\u2009years), adults (40\u201359\u00a0years), older adults (60\u201379\u2009years) and oldest adults (\u226580\u2009years). The prescriptions (ATC:level\u20103) were grouped into 0, 1\u20134, 5\u20139 (moderate polypharmacy) and \u226510 (excessive polypharmacy) and described 1\u00a0year pre\u2010IBD diagnosis, and 1, 2 and 3\u00a0years post\u2010IBD diagnosis. We estimated the risk of polypharmacy (moderate and excessive) 1\u2010year post\u2010IBD diagnosis in patients (\u226560\u2009years) using regression models, comparing recent to early years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 21\u2009255 young adults, 13\u2009432 adults, 8271 older adults and 933 oldest adults. The prevalence of moderate polypharmacy 1\u2010year post\u2010IBD diagnosis for young adults, adults, older adults and the oldest adults was 15.1, 23.2, 38.1 and 49.4%, respectively. The corresponding proportions for excessive polypharmacy were 1.5, 5.4, 16.6 and 23.4%, respectively. The adjusted odds ratio for polypharmacy among patients ages \u226560\u2009years in 2020\n                      <jats:italic>vs<\/jats:italic>\n                      . 1997 was 1.02 (95% confidence interval: 0.71\u20131.47).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of polypharmacy was high and increased with increasing age. In all age groups, the year\u2010by\u2010year level of polypharmacy was stable. For patients aged \u226560\u2009years, there were no signs of a decreasing trend. Polypharmacy seems to be an existing problem and awareness of ensuring appropriate prescribing is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70159","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:22:48Z","timestamp":1751847768000},"page":"3121-3129","source":"Crossref","is-referenced-by-count":0,"title":["The prevalence of polypharmacy increases with age among patients with inflammatory bowel disease: A nationwide cohort study"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-2926","authenticated-orcid":false,"given":"Ken","family":"Lund","sequence":"first","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital  Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology, Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-3062","authenticated-orcid":false,"given":"Jesper","family":"Ryg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Geriatric section Copenhagen University Hospital, Herlev and Gentofte  Copenhagen Denmark"},{"name":"Geriatric Research Unit, Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-0115","authenticated-orcid":false,"given":"Torben","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology Hospital of Southwest Jutland  Esbjerg Denmark"},{"name":"Department of Regional Health Science University of Southern Denmark  Esbjerg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8148-6572","authenticated-orcid":false,"given":"Jens","family":"Kjeldsen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastrointestinal Diseases Odense University Hospital  Odense Denmark"},{"name":"Research Unit of Medical Gastroenterology, Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-6812","authenticated-orcid":false,"given":"Jan","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital  Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology, Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Gastroenterology\/Hepatology Division Tufts Medical Center  Boston Massachusetts USA"},{"name":"Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2720-4404","authenticated-orcid":false,"given":"Sonia","family":"Friedman","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital  Odense Denmark"},{"name":"Gastroenterology\/Hepatology Division Tufts Medical Center  Boston Massachusetts USA"},{"name":"Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-6251","authenticated-orcid":false,"given":"Jimmy K.","family":"Limdi","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Sciences Faculty of Biology, Medicine &amp; 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