{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:39:16Z","timestamp":1774384756656,"version":"3.50.1"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012401","name":"Beijing Science and Technology Planning Project","doi-asserted-by":"publisher","award":["Z171100001017074"],"award-info":[{"award-number":["Z171100001017074"]}],"id":[{"id":"10.13039\/501100012401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Olanzapine steady\u2010state concentration can vary due to several factors. This study explores how physiological factors, smoking status, inflammation status, concomitant medications and metabolic enzyme single nucleotide polymorphisms (SNPs) influence its metabolic levels, aiming to guide personalized dosing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analysed data from 310 olanzapine\u2010treated patients at Beijing Anding Hospital. Liquid chromatography\u2013mass spectrometry quantified 1002 serum concentrations. Eleven SNPs from CYP1A2, CYP3A5, UGT1A4 and FMO1\/3 were identified through real\u2010time fluorescence quantitative polymerase chain reaction. A Bayesian network was applied to elucidate causal relationships between variables, followed by g\u2010computation to quantify the effect of individual factors on the dose\u2010adjusted concentration (C\/D ratio) of olanzapine. The Wilcoxon signed\u2010rank test assessed the intraindividual variations in the steady\u2010state C\/D ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Bayesian network suggested causality between smoking, sex, sertraline, Danggui\u2010Longhui, valproic acid and the olanzapine C\/D ratio. None of the SNPs reached significance levels. The Wilcoxon signed\u2010rank test confirmed that both polypharmacy and inflammation increased the C\/D ratio within individuals. G\u2010computation showed that the olanzapine C\/D ratio decreased by 1.135 in males and 0.821 with smoking. Danggui\u2010Longhui, sertraline and valproic acid reduced the ratio by 1.134, 0.92427 and 0.832, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study confirms that sex, age, smoking, inflammation and coprescription with sertraline, Danggui\u2010Longhui and valproic acid contributed to variability in olanzapine's steady\u2010state concentration. Considering these factors in clinical practice may help to personalize olanzapine treatment in Asian patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70161","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T05:30:08Z","timestamp":1751952608000},"source":"Crossref","is-referenced-by-count":1,"title":["Interindividual variability in olanzapine steady\u2010state concentrations in Chinese: exploring single nucleotide polymorphisms of metabolic enzymes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4717-8722","authenticated-orcid":false,"given":"Zhou","family":"Wan","sequence":"first","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing 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