{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:07Z","timestamp":1782518407066,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006183","name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006183","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006416","name":"Universidade Estadual de Campinas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study compares sequential nephron blockade (SNB) and renin\u2010angiotensin system sequential blockade (RASSB) in patients with resistant hypertension (RHTN), evaluating central systolic pressure, arterial stiffness, pulse pressure (PP) and ambulatory blood pressure monitoring (ABPM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy\u2010two RHTN patients were randomly assigned to SNB (n\u2009=\u200935, 22 females, 13 males) or RASSB (n\u2009=\u200937, 22 females, 15 males). SNB included multiple diuretics (furosemide, spironolactone, hydrochlorothiazide) to enhance natriuresis and counter intra\u2010renal compensatory mechanisms. RASSB employed stepwise renin\u2010angiotensin system blockade using lisinopril, bisoprolol and losartan, even in patients already on valsartan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Office blood pressure reductions were significant in both groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). SNB: systolic blood pressure (SBP) from 174.5 to 127.0\u00a0mmHg, diastolic blood pressure (DBP) from 105.3 to 78.11\u2009mmHg. RASSB: SBP from 178.4 to 134.4\u00a0mmHg, DBP from 102.7 to 77.33\u2009mmHg. ABPM confirmed 24\u2010h reductions (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). SNB showed greater PP reduction (\u0394\u2009=\u200922.99\n                      <jats:italic>vs<\/jats:italic>\n                      15.93\u2009mmHg,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.024) and central systolic pressure reduction (\u0394\u2009=\u2009\u221210.3\n                      <jats:italic>vs<\/jats:italic>\n                      \u20135.1\u00a0mmHg,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.036). RASSB produced a pronounced heart rate decrease (\u0394\u2009=\u2009\u221212.4\u00a0beats per minute,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). No treatment\u2010related discontinuations occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SNB demonstrated superior efficacy in reducing central SBP and PP, while RASSB more effectively lowered heart rate. These distinct hemodynamic responses support individualized treatment strategies for patients with RHTN.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT02832973.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70249","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:00:08Z","timestamp":1756274408000},"page":"186-197","source":"Crossref","is-referenced-by-count":2,"title":["RETRACTED: Effects of different antihypertensive drug classes on central and ambulatory blood pressure in resistant hypertension: A randomized clinical trial"],"prefix":"10.1002","volume":"92","author":[{"given":"Juan Carlos","family":"Yugar\u2010Toledo","sequence":"first","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2008-9287","authenticated-orcid":false,"given":"Tatiana Palotta","family":"Minari","sequence":"additional","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla Galisteu","family":"de Mello","sequence":"additional","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"do Espirito Santo Cestario","sequence":"additional","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto  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