{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:38:53Z","timestamp":1770910733645,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In haematopoietic cell transplantation (HCT), neutropenia resulting from myelosuppression is an expected endpoint following busulfan\u2010based conditioning. However, if prolonged, neutropenia can lead to complications like serious infection and death. The routine use of pharmacokinetic (PK)\u2010guided busulfan dosing has decreased toxicities; however, patients still have serious, sometimes fatal, complications of drug\u2010induced neutropenia. We sought to investigate whether the time\u2010course of neutropenia after HCT could be predicted for paediatric patients following busulfan\u2010based conditioning. Such predictions could guide care, such as timing of infectious prophylaxis and\/or growth factor administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single\u2010centre, retrospective study of 146 patients with malignant or nonmalignant disorders treated with allogeneic or autologous HCT. An advanced PKPD model of neutrophil dynamics post\u2010HCT was built that included two parallel neutrophil maturation pathways for host and donor cells, expanded transit compartments for neutrophil maturation, cell number\u2010based feedback loops to the proliferating compartment, GCSF effects, and direct\/indirect busulfan killing effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The model predicted neutrophil recovery well using patient data beyond Day +21 post\u2010HCT. When using patient data prior to Day +21 post\u2010HCT, neutrophil recovery was less accurate (as measured by the sum of the absolute neutrophil count prediction error) due to unpredictable complications influencing neutrophil counts. Four clinical cases illustrate the strengths and challenges of the model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests real\u2010time incorporation of patient\u2010specific data through Day +21 post\u2010HCT is required to predict neutrophil dynamics following neutrophil nadir in paediatric HCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70251","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:21:41Z","timestamp":1759123301000},"page":"568-578","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of neutrophil nadir and recovery following paediatric haematopoietic cell transplantation with busulfan conditioning"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6909-8072","authenticated-orcid":false,"given":"Beth","family":"Apsel Winger","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology UCSF  San Francisco CA USA"},{"name":"Department of Clinical Pharmacy UCSF  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph W.","family":"Polli","sequence":"additional","affiliation":[{"name":"Discovery DMPK ViiV Healthcare  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janel","family":"Long\u2010Boyle","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy UCSF  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Weber","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology ViiV Healthcare  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy UCSF  San Francisco CA 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