{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:44:17Z","timestamp":1792601057727,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016714","name":"University of Sharjah","doi-asserted-by":"publisher","award":["24010901166"],"award-info":[{"award-number":["24010901166"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Older men with type 2 diabetes mellitus (T2DM) face a heightened risk of sarcopenia. This study aimed to compare the longitudinal effects of semaglutide, a glucagon\u2010like peptide\u20101 receptor agonist and sitagliptin as the control group on sarcopenia indicators and biomarkers of neuromuscular junction and neuronal health in patients with T2DM over 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cohort of 141 older men with T2DM (semaglutide,\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u00a068; sitagliptin group,\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u00a073) underwent assessments at baseline, 6\u00a0months and 1 year. Measured parameters included handgrip strength (HGS), gait speed, appendicular skeletal muscle mass index (ASMI), short physical performance battery (SPPB) and plasma concentrations of C\u2010terminal agrin fragment 22 (CAF22), neurofilament light chain (NfL) and brain\u2010derived neurotrophic factor (BDNF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over the study period, the semaglutide group exhibited significant reductions in HGS, gait speed, ASMI and SPPB scores (all\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u2009.05). Concurrently, this group exhibited more pronounced elevation of plasma CAF22 and NfL levels compared to the sitagliptin group (all\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u2009.05). Among the patients taking semaglutide, higher CAF22 and NfL levels generally correlated with poorer HGS, ASMI and SPPB scores. In contrast, lower BDNF levels were associated with reduced ASMI and SPPB at specific time points (all\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u2009.05). Multiple regression analysis confirmed significant negative associations between CAF22 and NfL, and a positive association between BDNF and sarcopenia parameters, specifically among patients taking semaglutide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide treatment in older men with T2DM may be associated with a decline in muscle strength and physical performance, potentially associated with neuromuscular junction degradation and neuronal damage. These findings underscore the importance of closely monitoring musculoskeletal health in patients receiving semaglutide.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70253","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:19:03Z","timestamp":1756189143000},"page":"149-161","source":"Crossref","is-referenced-by-count":12,"title":["Semaglutide use is associated with neuromuscular junction degradation in older adults with type II diabetes mellitus"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-7172","authenticated-orcid":false,"given":"Rizwan","family":"Qaisar","sequence":"first","affiliation":[{"name":"Basic Medical Sciences College of Medicine, University of Sharjah  Sharjah United Arab Emirates"},{"name":"Space Medicine Research Group, Research Institute of Medical and Health Sciences University of Sharjah  Sharjah United Arab Emirates"},{"name":"Cardiovascular Research Group, Research Institute of Medical and Health Sciences University of Sharjah  Sharjah United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran Ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Rehman Medical Institute  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Medicine Divisional Headquarters Hospital  Kohat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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