{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:13:08Z","timestamp":1789445588906,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V111B\u2010043"],"award-info":[{"award-number":["V111B\u2010043"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C\u2010141"],"award-info":[{"award-number":["V113C\u2010141"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V114C\u2010005"],"award-info":[{"award-number":["V114C\u2010005"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V114C\u2010234"],"award-info":[{"award-number":["V114C\u2010234"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled. Patients were categorized into two groups based on HCTZ use. Factors associated with combination therapy and clinical outcomes were examined. Effectiveness outcomes included weight change and percentage weight change, while safety outcomes focused on acute kidney injury (AKI) and worsening renal function at discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 3493 enrolled patients, 329 received combination therapy. Factors associated with combination therapy included use of thiazide diuretics pre\u2010admission (adjusted odds ratio [aOR]: 1.81; 95% confidence interval [CI]: 1.25\u20132.62), pre\u2010admission dose of oral loop diuretics (aOR: 1.28 per defined daily dose; 95% CI: 1.05\u20131.56), lower estimated glomerular filtration rate (aOR: 0.98 per unit; 95% CI: 0.98\u20130.99), higher N\u2010terminal pro\u2010B\u2010type natriuretic peptide levels (aOR: 1.02 per 1000 unit; 95% CI: 1.01\u20131.02), and lower serum albumin (aOR: 0.53 per unit; 95% CI: 0.41\u20130.68). Compared to loop diuretics monotherapy, weight reduction was greater in combination therapy (adjusted difference \u22121.2\u00a0kg; 95% CI: \u22121.5 to \u22120.9) and percentage of weight loss (adjusted difference \u22121.8%; 95% CI: \u22122.3 to \u22121.3), but higher risk of AKI (aOR: 2.7; 95% CI: 2.1\u20133.5) and worsening renal function at discharge (aOR: 2.4; 95% CI: 1.9\u20133.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combination therapy enhanced weight reduction in ADHF; however, it might increase the risk of renal dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70257","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:04:32Z","timestamp":1756285472000},"page":"220-229","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and safety of combining thiazides with loop diuretics\n                    <i>vs<\/i>\n                    . loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-716X","authenticated-orcid":false,"given":"Chia\u2010Chen","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Pharmacy, College of Pharmaceutical Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien\u2010Chih","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Pharmacy, College of Pharmaceutical Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Chieh","family":"Wung","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Pharmacy, College of Pharmaceutical Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Pharmacy National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh\u2010Ching","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Pharmacy, College of Pharmaceutical Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Pharmacology, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh\u2010Lih","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Pharmacy, College of Pharmaceutical Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Pharmacology, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chian\u2010Ying","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Pharmacy, College of Pharmaceutical Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4217-8734","authenticated-orcid":false,"given":"Chin\u2010Chou","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of Cardiology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.121.008943"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.7472"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010024\u201001046\u20106"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2022.28.2.157"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027852"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.034"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201096002\u20106"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac689"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10184207"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009149"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq433"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010130\u20106\u2010199903160\u201000002"},{"key":"e_1_2_11_17_1","unstructured":"World Health Organization.Collaborating Centre for Drug Statistics Methodology. ATC\/DDD Index 2025. Accessed July 26 2025.https:\/\/atcddd.fhi.no\/atc_ddd_index\/"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2872"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5713"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15537"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.03.030"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13696"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256\u2010023\u201000571\u2010y"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.215"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.07.006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1113"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102018\u2010314158"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad335"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260312"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu065"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392\u2010015\u20100896\u20102"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016111178"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2988"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.924173"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030112"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12788"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.02.026"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rceng.2023.11.003"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.05.004"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae146"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bcp.70257","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:36:01Z","timestamp":1769146561000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/bcp.70257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/bcp.70257"],"URL":"https:\/\/doi.org\/10.1002\/bcp.70257","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]}}}