{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:54:52Z","timestamp":1789167292616,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    There is no prospective research on factors influencing posaconazole (PSCZ)\u2010tacrolimus (TAC) interactions. This prospective observational study analysed 30 allogeneic haematopoietic cell transplantation recipients: 19 started PSCZ while receiving oral (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) or intravenous (IV) TAC (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099) and 11 switched from IV to oral TAC during PSCZ administration. Following PSCZ initiation, the median TAC dose reductions were 45% for oral and 39% for IV TAC. Oral TAC concentration\u2010to\u2010dose ratios (C\/D) significantly increased over 2\u2009weeks (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.01) and correlated with PSCZ concentrations (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u20090.92,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.01), whereas IV TAC C\/D showed no significant changes or correlations. The median IV to oral TAC conversion ratio was 2.86. Linear regression analyses revealed significant associations between PSCZ concentrations and oral TAC C\/D changes,\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    polymorphisms and IV TAC C\/D changes, and\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    polymorphisms and TAC conversion ratios. TAC route, PSCZ concentrations and genetic polymorphisms may influence PSCZ\u2013TAC interactions.\n                  <\/jats:p>","DOI":"10.1002\/bcp.70264","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T06:14:46Z","timestamp":1756966486000},"page":"3288-3296","source":"Crossref","is-referenced-by-count":1,"title":["Effects of routes, concentrations and genetic polymorphisms on posaconazole\u2013tacrolimus interactions in allogeneic haematopoietic cell transplantation"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-147X","authenticated-orcid":false,"given":"Masatomo","family":"Kuno","sequence":"first","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Okayama","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan 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