{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:07:25Z","timestamp":1773011245768,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD105297"],"award-info":[{"award-number":["R21HD105297"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["P50MH68036"],"award-info":[{"award-number":["P50MH68036"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To characterize pharmacokinetic changes of sertraline and its metabolite during pregnancy and postpartum, and their relationship to maternal postpartum depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective observational, longitudinal study of pregnant women with a major depressive disorder treated with sertraline (N\u2009=\u2009185 women, 205 pregnancies). Women were enrolled at &lt;16 weeks' gestation and followed at 4\u20108\u2009week intervals throughout pregnancy and the first postpartum year. Baseline measures included structured clinical interviews and demographic information. Drug and metabolite concentrations and psychometric measures (study outcomes) (ie, Hamilton Rating Scale for depression \u2013 17 item, Beck Depression Inventory, Edinburgh Postnatal Depression Scale [EPDS], Clinical Global Impression [CGI]) were measured at follow\u2010up visits. Serum sertraline and N\u2010desmethylsertraline exposure were reported asstandardized 24\u2010h concentration\u2010to\u2010dose (C\/D) and parent to metabolite (P\/M) ratios. Linear mixed\u2010effects and latent trajectory models were used to characterize longitudinal patterns in concentration measures across pregnancy and postpartum, and their association with study outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean 24\u2010h C\/D ratios showed high variability throughout pregnancy and postpartum that were characterized by three trajectories for sertraline and five for N\u2010desmethylsertraline and P\/M ratio corresponding to different sertraline pharmacokinetic profiles. At postpartum, sertraline drug exposure was inversely associated with higher EPDS score (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u2009.05), while N\u2010desmethylsertraline exposure was associated with higher scores for all measured depression scales (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u2009.001). Higher P\/M ratios had higher CGI scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u2009.05) postpartum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sertraline pharmacokinetic profiles varied across pregnant women and were associated with postpartum depressive symptoms. The use of therapeutic monitoring may provide clinical insight that can be useful for identifying patients with a potential toward depressive symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70283","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T04:25:50Z","timestamp":1759897550000},"page":"830-839","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetic profiles of sertraline in pregnancy as a predictor of postpartum depressive symptoms"],"prefix":"10.1002","volume":"92","author":[{"given":"S\u00edlvia M.","family":"Illamola","sequence":"first","affiliation":[{"name":"Experimental and Clinical Pharmacology Department University of Minnesota  Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary N.","family":"Stowe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Wisconsin at Madison  Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc L.","family":"Kalin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Wisconsin at Madison  Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Evans","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Institute University of Minnesota  Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0844-3207","authenticated-orcid":false,"given":"Catherine M.","family":"Sherwin","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Pharmacology Department University of Minnesota  Minneapolis MN USA"},{"name":"Internal Medicine, UWA Medical School The University of Western Australia  Perth Western Australia Australia"},{"name":"Differentia Bio, South San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maged M.","family":"Costantine","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics &amp; Gynecology The Ohio State University Wexner Medical Center  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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