{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:25:38Z","timestamp":1791239138356,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005747","name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","award":["L\u20102023\u201000147"],"award-info":[{"award-number":["L\u20102023\u201000147"]}],"id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009910","name":"Hartmann Fonden","doi-asserted-by":"publisher","award":["A39035"],"award-info":[{"award-number":["A39035"]}],"id":[{"id":"10.13039\/501100009910","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to describe prescription use of acetaminophen, a widely used analgesic and antipyretic generally considered safe during pregnancy, among pregnant women from 2000 to 2023 in Denmark with special attention towards variations following the change in over\u2010the\u2010counter (OTC) availability in 2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this population\u2010based drug utilization study, individually linked data from nationwide health registries on pregnant women in Denmark between 2000 and 2023 were used to evaluate time trends on prescription use of acetaminophen and describe distributions of maternal characteristics among prescription\u2010based drug users and non\u2010users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1\u2009446\u2009841 eligible pregnancies included, 27 per 1000 pregnant women redeemed at least one prescription for acetaminophen during pregnancy, and among these, 18% redeemed more than one. In 2023, 74 per 1000 pregnancies were exposed to prescription use of acetaminophen. Relative to non\u2010users, prescription\u2010based drug users were generally older and had a higher body mass index. They more frequently presented with pain\u2010related, chronic or psychiatric conditions and used other prescription medications throughout the study period. However, these differences were less pronounced in the cohort restricted to pregnancies ending in 2015\u20132023 compared to 2000\u20132012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prescription use of acetaminophen in the pregnant population in Denmark has increased since 2000, with a notable sharp increase from 2013 onwards, coinciding with the regulatory restriction that reduced over\u2010the\u2010counter pack sizes, alongside a concurrent rise in general\u2010population prescription use. Prescription\u2010based drug users were more likely to have comorbidities and multiple medication use than non\u2010users, although these differences have become less pronounced in recent years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70296","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:10:02Z","timestamp":1758967802000},"page":"556-567","source":"Crossref","is-referenced-by-count":3,"title":["Prescription use of acetaminophen among pregnant women in Denmark from 2000 to 2023: A drug utilization study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7193-9993","authenticated-orcid":false,"given":"Erika B.","family":"Gram","sequence":"first","affiliation":[{"name":"Research Unit of Clinical Pharmacology, Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Bliddal","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"},{"name":"Research Unit OPEN, Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Pflugfelder","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Pharmacology, Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Bj\u00f8dstrup","family":"Jensen","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-7187","authenticated-orcid":false,"given":"Per","family":"Damkier","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Pharmacology, Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Clinical Pharmacology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"B14","article-title":"Society for Maternal\u2010Fetal Medicine (SMFM) publications committee","volume":"216","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010016\u20100582\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12814"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005802"},{"key":"e_1_2_10_6_1","unstructured":"U.S. Food and Drug Administration.FDA recommends avoiding use of NSAIDs in pregnancy at 20 weeks or later because they can result in low amniotic fluid. 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