{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:06:26Z","timestamp":1775433986337,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007543","name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate if exposure to beta\u2010blockers during the first trimester of pregnancy increases the risk of congenital anomaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational comparative study was carried out. This study was conducted using EFEMERIS, a medico\u2010administrative database. We included women who had a pregnancy between 2004 and 2021 registered in EFEMERIS. Comparison of women receiving beta\u2010blockers during the first trimester of pregnancy with those receiving calcium channel blockers and with women unexposed to antihypertensive medications. Logistic regression models adjusted for relevant confounders were used to estimate the adjusted odds ratios (ORa) for major congenital anomalies. We calculated the ajusted Odds Ratio (ORa) and its 95% confidence intervals (CI) for major congenital anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 1813 pregnant women (1%) exposed to beta\u2010blockers, 2903 (1.6%) exposed to calcium channel blockers and 172\u2009284 unexposed to any antihypertensive medication were compared. Multivariate analyses showed a statistically significant increased risk of major congenital anomalies in fetuses\/children exposed to beta\u2010blockers (ORa[95% CI]\u2009=\u00a01.56 [1.07\u20132.18]) compared with unexposed group. However, this increased risk was not observed when comparing with women exposed to calcium channel blockers (ORa[95% CI]\u2009=\u00a00.71 [0.29\u20132.15]). An increased risk of major congenital anomalies was also observed in fetuses\/children exposed to labetalol compared with those unexposed to antihypertensive medications (ORa [95% CI]\u2009=\u00a02.00 [1.06\u20133.40]), but not when compared with those exposed to calcium channel blockers (ORa [95% CI]\u2009=\u00a01.06 [0.37\u20133.48]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study found no increased risk of major congenital anomalies in women exposed to beta\u2010blockers compared with those exposed to calcium channel blockers in early pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70322","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T14:06:22Z","timestamp":1763129182000},"page":"1051-1057","source":"Crossref","is-referenced-by-count":0,"title":["Risk of major congenital anomalies and beta\u2010blockers: A comparative study from the EFEMERIS database"],"prefix":"10.1002","volume":"92","author":[{"given":"Laurane","family":"Delteil","sequence":"first","affiliation":[{"name":"R\u00e9seau Regards, Pharmacologie M\u00e9dicale Et Clinique Centre Hospitalier Universitaire De Toulouse, INSERM Cerpop  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Vial","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Service Hospitalo\u2010Universitaire de Pharmacotoxicologie, Hospices civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Gautier","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Nord Pas de Calais, service hospitalo\u2010universitaire de pharmacologie m\u00e9dicale CHU de Lille  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie\u2010Pierre","family":"Jonville","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Centre Val de Loire, Service de PHarmacosurveillance CHU de Tours  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Amar","sequence":"additional","affiliation":[{"name":"Service d'hypertension art\u00e9rielle CHU de Toulouse  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Masset","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 des produits de Sant\u00e9 (ANSM)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Massardier","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie Obst\u00e9trique et M\u00e9decine F\u0153tale, H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatiha","family":"Karam","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie Obst\u00e9trique et M\u00e9decine F\u0153tale, H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-7282","authenticated-orcid":false,"given":"Isabelle","family":"Lacroix","sequence":"additional","affiliation":[{"name":"R\u00e9seau Regards, Pharmacologie M\u00e9dicale Et Clinique Centre Hospitalier Universitaire De Toulouse, INSERM Cerpop  France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010023\u201001234\u20108"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44043"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100338"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00833"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010017\u20100627\u2010x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14561"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010009\u20100647\u20102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002046"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1370797"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0306547"},{"key":"e_1_2_11_12_1","unstructured":"European Society of Cardiology.Hypertension in pregnancy.2019[cited 2025 Jun 12]. 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