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Here the PK\u2013PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment asymptotically approaching zero, requiring a cure threshold to be selected. We implemented an alternative stochastic model, where parasite\u2010time profiles were simulated using a binomial function with an hourly parasite survival probability. This probabilistic model enables a time of exact cure to be calculated, when zero parasites remain. The 28\u2010day cure rates predicted by the deterministic and stochastic models for multiple antimalarial treatment strategies were equivalent, with an absolute difference ranging from \u22120.8% to 3.1% (mean of 0.48%, positive values indicate higher stochastic model cure rates). 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