{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:37:55Z","timestamp":1787593075504,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the prevalence of frailty in older adults with atrial fibrillation (AF) and the association between frailty with oral anticoagulant (OAC) prescription and hospitalization, with a focus on variations by sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults aged \u226560\u2009years with AF were recruited at two hospitals in Vietnam from 2022 to 2024. Frailty was defined by the Clinical Frailty Scale (CFS). Logistic regressions were conducted to examine the association between CFS with OAC prescription and cardiovascular\u2010related hospitalization over 6\u00a0months. Results are presented as odds ratios (ORs) and 95% confidence intervals (CIs). The women\u2010to\u2010men ratios of ORs and 95% CIs were calculated to quantify how the ORs differed between the sexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 1210 participants (513 women, 697 men, mean age 74). The prevalence of frailty was 40.7% (46.8% in women\n                      <jats:italic>vs<\/jats:italic>\n                      . 36.3% in men, p\u2009&lt;\u20090.001). With every unit increase in the CFS, the adjusted ORs for OAC prescription were 0.70 (95% CI 0.54\u20130.90) in women, 0.97 (95% CI 0.74\u20131.28) in men (women\u2010to\u2010men ratio of ORs 0.72, 95% CI 0.50\u20131.05). CFS score predicted cardiovascular\u2010related hospitalization: adjusted ORs 1.65 (95% CI 1.29\u20132.10) in women, 2.04 (95% CI 1.62\u20132.59) in men, women\u2010to\u2010men ratio of ORs 0.81 (95% CI 0.58\u20131.13).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Frailty was more common and was associated with reduced odds of receiving OAC in women. There was a trend of increased impact of frailty on cardiovascular\u2010related hospitalization in men compared to women. Further studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70390","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T12:10:04Z","timestamp":1764850204000},"page":"1213-1220","source":"Crossref","is-referenced-by-count":1,"title":["Sex differences in how frailty affects treatment and outcomes in older adults with atrial fibrillation"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-8920","authenticated-orcid":false,"given":"Tu","family":"Nguyen","sequence":"first","affiliation":[{"name":"The George Institute for Global Health  Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0234-6596","authenticated-orcid":false,"given":"Tan Van","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics 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