{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:21:52Z","timestamp":1781108512718,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Cefoperazone\/sulbactam (CPZ\/SUL) is a broad\u2010spectrum \u03b2\u2010lactam\/\u03b2\u2010lactamase inhibitor combination. Drug\u2010induced immune haemolytic anaemia (DIIHA) is a rare yet serious condition, whereas reactive thrombocytosis typically occurs as a secondary response to inflammatory, infectious or neoplastic processes. We report a case of a 58\u2010year\u2010old woman who presented with haemolytic anaemia and reactive thrombocytosis following administration of CPZ\/SUL for pneumonia. The patient underwent neuroendoscopic evacuation of the intracranial haematoma, followed by decompressive craniectomy and debridement. Following 15\u2009days of CPZ\/SUL therapy, serial blood tests revealed a progressive decline in haemoglobin (HB), haematocrit (HCT) and red blood cell count, accompanied by a marked elevation in platelet count. Furthermore, the strongly positive anti\u2010IgG (+++) and negative anti\u2010C3d direct antiglobulin test results, together with the clinical and laboratory profile, confirmed the diagnosis of haemolytic anaemia and reactive thrombocytosis. After discontinuing CPZ\/SUL and providing intermittent red blood cell transfusions over 7\u2009days, the patient's haematological parameters normalized, which permitted discharge. This case presented a rare occurrence of CPZ\/SUL\u2010induced haemolytic anaemia and thrombocytosis, classified as \u2018probable\u2019 according to the Naranjo algorithm. This case describes a rare, suspected association between CPZ\/SUL therapy and the concurrent development of immune haemolytic anaemia and reactive thrombocytosis. Clinicians should maintain awareness of these potential adverse haematological reactions during CPZ\/SUL treatment and institute regular complete blood count monitoring.<\/jats:p>","DOI":"10.1002\/bcp.70422","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:25:38Z","timestamp":1768897538000},"page":"1493-1499","source":"Crossref","is-referenced-by-count":1,"title":["Cefoperazone\/sulbactam\u2010induced haemolytic anaemia and thrombocytosis: A case report and literature review"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1541-0611","authenticated-orcid":false,"given":"Quanji","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pharmacy Guangyuan Central Hospital  Guangyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Diseases Guangyuan Central Hospital  Guangyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shugai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Diseases Guangyuan Central Hospital  Guangyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guangyuan Central Hospital  Guangyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guangyuan Central Hospital  Guangyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Guangyuan Central Hospital  Guangyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Guangyuan Central Hospital  Guangyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1228142"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123859"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2021.12.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979\u2010020\u201000208\u20107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpgm.JPGM_1335_20"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01342"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121\u2010022\u201000672\u20102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky323"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9020077"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.11.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.32725\/jab.2023.010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.08.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084296"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.100648"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2022.2089115"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023009801"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2017.05.013"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.697192"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3343\/kjlm.2009.29.6.578"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102561\u20108818"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.02.010"},{"issue":"1","key":"e_1_2_10_23_1","first-page":"79","article-title":"Acute myocardial infarction in a patient with post\u2010splenectomy thrombocytosis: a case report and review of literature","volume":"17","author":"Ghaffari S","year":"2010","journal-title":"Cardiol J"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/3056216"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9282\u201021"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806\u20109282.20230020"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2010.08122.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(94)90306\u20109"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2720"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028018819450"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.1263"},{"issue":"7","key":"e_1_2_10_32_1","first-page":"65","article-title":"Drug\u2010induced autoimmune hemolytic anemia, leukopenia and thrombocytosis in pulmonary tuberculosis","author":"Cherednichenko LP","year":"1980","journal-title":"Probl Tuberk"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010007\u20109145\u20108"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bcp.70422","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:16:18Z","timestamp":1777792578000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/bcp.70422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/bcp.70422"],"URL":"https:\/\/doi.org\/10.1002\/bcp.70422","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]}}}