{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:32:48Z","timestamp":1792798368112,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Hyponatremia is a common yet potentially serious adverse event associated with antidepressants. Identifying the antidepressant class with the least risk of hyponatremia would improve patient safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using electronic medical records from 15 hospitals standardized into Observational Medical Outcomes Partnership Common Data Model (2003\u20132023), we identified patients diagnosed with depression who initiated antidepressants, including selective serotonin reuptake inhibitor (SSRI), serotonin\u2013norepinephrine reuptake inhibitor (SNRI), tricyclic antidepressants (TCA) or others (agomelatine, bupropion, mirtazapine, moclobemide and trazodone) for at least 30\u2009days. The index date was defined as the first antidepressant prescription, and four mutually exclusive cohorts were constructed based on the antidepressant class prescribed on index date. Each cohort was compared with all other antidepressants. The primary outcome was incident hyponatremia (serum sodium &lt;135\u2009mmol\/L) within the first 180\u2009days. After propensity score stratification, hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression. Fixed\u2010effect meta\u2010analysis was used to pool the results from each site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 17\u2009895 (42.6%) patients in SSRI, 7395 (17.6%) in SNRI, 5424 (12.9%) in TCA and 11\u2009322 (26.9%) in other group. The risk of hyponatremia increased within 180\u2009days after SSRI initiation (HR 1.18, 95% CI 1.01\u20131.38) compared with all other depressants, with a higher risk in patients aged \u226560\u2009years (1.29, 1.06\u20131.57). No significant association was found for SNRIs (1.05, 0.87\u20131.27), TCAs (1.03, 0.84\u20131.26) or other (0.90, 0.77\u20131.06).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Close monitoring of serum sodium levels is essential for SSRI users, especially those aged \u226560\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70441","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:56:39Z","timestamp":1768377399000},"page":"1706-1715","source":"Crossref","is-referenced-by-count":3,"title":["Antidepressants and the risk of hyponatremia: A multi\u2010institutional cohort study using observational medical outcomes partnership\u2014Common Data Model"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0990-9360","authenticated-orcid":false,"given":"Kyungyeon","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Biohealth Regulatory Science Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-6515","authenticated-orcid":false,"given":"Ju Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biohealth Regulatory Science Sungkyunkwan University  Suwon South Korea"},{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0714-5673","authenticated-orcid":false,"given":"Da Eun","family":"Hyeon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Ajou University Graduate School of Medicine  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5391-2057","authenticated-orcid":false,"given":"Jeongmoon","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Biohealth Regulatory Science Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1347-0493","authenticated-orcid":false,"given":"Min Young","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8404-8006","authenticated-orcid":false,"given":"Hayun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Veteran Health Service Medical Center  Seoul South Korea"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario 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