{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:08:38Z","timestamp":1784099318380,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To develop and validate a multidimensional tool to assess adherence to warfarin therapy by Brazilian patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Tool for Assessing Adherence to Warfarin Therapy (TAAW) was designed to encompass warfarin intake and other treatment\u2010related aspects, including causal and effect items of adherence. The development process included: (i) construction of a concept map; (ii) elaboration of a preliminary version; (iii) expert assessment; (iv) semantic analysis through pre\u2010testing with 30 participants; and (v) psychometric validation, including exploratory factor analysis, internal consistency, test\u2013retest reliability and hypothesis testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 35 initially drafted items, 14 were discarded and 19 modified, resulting in a final version with 21 items distributed across three dimensions: warfarin intake (n\u2009=\u200910), self\u2010care associated with warfarin use (n\u2009=\u20097) and health monitoring (n\u2009=\u20094). The TAAW tool demonstrated a unidimensional structure, excellent internal consistency (Cronbach's alpha\u2009=\u20090.98), high test\u2013retest reliability (Intraclass Correlation Coefficient\u2009=\u20090.96) and strong correlation with the time in therapeutic range (Spearman's rho\u2009=\u20090.91), confirming its validity and reliability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The validated TAAW is a robust instrument for assessing adherence to warfarin therapy in clinical and research settings. Its comprehensive approach allows for the identification of adherence patterns, enabling healthcare professionals to implement targeted interventions and optimize anticoagulation outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70467","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:14:32Z","timestamp":1770264872000},"page":"2063-2074","source":"Crossref","is-referenced-by-count":0,"title":["Development and validation of a tool assessing adherence to warfarin therapy (TAAW) by Brazilian patients"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-0998","authenticated-orcid":false,"given":"Carolina Barbosa","family":"Ferreira","sequence":"first","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1427-2149","authenticated-orcid":false,"given":"Mayara Sousa","family":"Vianna","sequence":"additional","affiliation":[{"name":"Pr\u00f3\u2010Reitoria de Apoio \u00e0 Perman\u00eancia Estudantil \u2010 Prape, Universidade Federal De Lavras, Trevo Rotat\u00f3rio Professor Edmir S\u00e1 Santos  Lavras Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-3503","authenticated-orcid":false,"given":"Adriana Silvina","family":"Pagano","sequence":"additional","affiliation":[{"name":"Faculdade de Letras, Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-8779","authenticated-orcid":false,"given":"Cristiane Baccin","family":"Bendo","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-0287","authenticated-orcid":false,"given":"Raiane Costa","family":"Viana","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-2399","authenticated-orcid":false,"given":"Daniella Vieira","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3858-1632","authenticated-orcid":false,"given":"Ana Julia Alves","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7199-8590","authenticated-orcid":false,"given":"Ilka Afonso","family":"Reis","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Exatas, Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-6926","authenticated-orcid":false,"given":"Marcus Fernando","family":"da Silva Praxedes","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rec\u00f4ncavo da Bahia  Santo Antonio de Jesus Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-411X","authenticated-orcid":false,"given":"Maria Auxiliadora Parreiras","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11\u20102292"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100038\u20101675816"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2295"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15437"},{"key":"e_1_2_11_6_1","unstructured":"World Health Organization.Adherence to long\u2010term therapies: evidence for action. 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