{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:06:02Z","timestamp":1779782762995,"version":"3.53.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The serum creatinine\u2013to\u2013cystatin C ratio (Cr\/Cys\u2010C) has recently garnered interest as a simpler surrogate marker for sarcopenia assessment. However, the reported Cr\/Cys\u2010C thresholds vary in different disease states, and Cr\/Cys\u2010C is yet to be established as a reliable diagnostic marker. This study aimed to identify a Cr\/Cys\u2010C threshold at which Cys\u2010C\u2013based estimated glomerular filtration rate (eGFRcys) provides more accurate renal function assessment than Cr\u2013based eGFR (eGFRcr) for informing drug dosing strategies in sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 172 patients who had been receiving a consistent dose of oral magnesium oxide for at least one week and had undergone same\u2010day measurements of serum Cr, Cys\u2010C and magnesium (Mg). Based on previously reported Cr\/Cys\u2010C thresholds (&lt; 0.887, &lt; 0.80 and &lt; 0.67), patients were stratified into sarcopenia and non\u2010sarcopenia cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all subjects, eGFRcr and eGFRcys each demonstrated a significant negative correlation with serum Mg level. At Cr\/Cys\u2010C thresholds of &lt; 0.80 and &lt; 0.67, serum Mg level showed a significant inverse correlation with eGFRcys in both sarcopenia and non\u2010sarcopenia cohorts, but did not correlate significantly with eGFRcr in the sarcopenia cohort. ROC analysis identified an optimal Cr\/Cys\u2010C cutoff of 0.82 at which serum Mg level correlates significantly with eGFRcys but not with eGFRcr, yielding a sensitivity of 100% and specificity of 69.23%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that at Cr\/Cys\u2010C below 0.82, the accuracy of eGFRcr in assessing renal function may be compromised, and eGFRcys should be used in such cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70469","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:38:23Z","timestamp":1769607503000},"page":"1857-1866","source":"Crossref","is-referenced-by-count":0,"title":["Creatinine\/cystatin C ratio\u2010guided selection of renal function marker in sarcopenia"],"prefix":"10.1002","volume":"92","author":[{"given":"Rina","family":"Kamiya","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Oita University Hospital  Yufu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-7971","authenticated-orcid":false,"given":"Ryota","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Oita University Hospital  Yufu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Tsushita","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Oita University Hospital  Yufu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4949-362X","authenticated-orcid":false,"given":"Ryosuke","family":"Tatsuta","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Oita University Hospital  Yufu Oita 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