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The latest research has revealed that the potential of CAR T\u2010cell therapy extends far beyond its current capabilities and could represent a novel therapeutic approach for treating various cancers. This review aims to summarize the latest innovations in CAR T\u2010cell therapy applied in cancer treatment, including multiple myeloma, osteosarcoma, glioblastoma, melanoma and various childhood malignancies. However, several challenges limit success of CAR T\u2010cell therapy, including the antigen escape phenomenon, \u2018on\u2010target off\u2010tumour\u2019 toxicity, penetration into solid tumour tissue, alongside the cost\u2010effectiveness concerns. The improvement of cancer immunotherapies currently available requires an increase in the effectiveness of CAR T\u2010cells in managing refractory and solid cancers. This could be achieved by using CAR T\u2010cells to target various antigens, enhancing their local delivery and tumour infiltration capabilities and utilizing CAR T\u2010cells in combination with checkpoint blockade and immunotherapy, such as PD\u20101 blockade and CD19 CAR T\u2010cell combined therapy. Although CAR T\u2010cell treatment offers a lot of promise, its cost needs to be taken into account, especially in healthcare systems with limited funding. More importantly, frameworks for Health Technology Assessment (HTA) must adapt to incorporate ethical, sociological and psychological aspects. Reducing CAR T\u2010cell toxicity is also essential, as it remains among biggest obstacles to their widespread application in clinical practice. Future research should therefore focus on enhancing our understanding of CAR T\u2010cell therapy and expanding the application of immunotherapy in treatment.<\/jats:p>","DOI":"10.1002\/bcp.70478","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:35:23Z","timestamp":1771486523000},"source":"Crossref","is-referenced-by-count":1,"title":["Efficacy, safety and cost\u2010effectiveness of CAR\u2010T therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0913-5759","authenticated-orcid":false,"given":"Emina Karahmet","family":"Sher","sequence":"first","affiliation":[{"name":"International Society of Engineering Science and Technology  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"D\u017eidi\u0107\u2010Krivi\u0107","sequence":"additional","affiliation":[{"name":"International Society of Engineering Science and Technology  Nottingham UK"},{"name":"Department of Neurology Clinical 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