{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:06:19Z","timestamp":1779782779028,"version":"3.53.1"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The study's aim is to report the first documented paediatric case of generalized Erythema Scarlatiniforme Desquamativum Recidivans (ESDR), or F\u00e9r\u00e9ol\u2010Besnier disease, induced by amoxicillin and to assess the cross\u2010reactivity profile to other beta\u2010lactam antibiotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An 8\u2010year\u2010old boy with a history of recurrent episodes of diffuse, itchy erythema and subsequent lamellar desquamation following amoxicillin\/amoxicillin\u2013clavulanic acid intake was assessed. Causality was evaluated based on clinical history, exclusion of infectious and other drug\u2010related etiologies, skin biopsy and a positive oral provocation test (OPT) with amoxicillin. Cross\u2010reactivity to other beta\u2010lactams was assessed using OPTs with phenoxymethylpenicillin, oxacillin, and cefadroxil. Causality was scored using the Naranjo probability scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The temporal relationship, resolution after drug withdrawal, and a positive amoxicillin OPT confirmed the diagnosis of amoxicillin\u2010induced generalized ESDR. The Naranjo score was 8, classifying the reaction as \u2018probable\u2019 triggered by amoxicillin. Intradermal and patch tests to amoxicillin\u2013clavulanic acid were negative. The OPTs for phenoxymethylpenicillin and oxacillin were negative. However, the OPT with cefadroxil yielded a positive reaction at the second step (one fourth of the daily dose), indicating a selective aminopenicillin\u2013aminocephalosporin cross\u2010reactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case establishes the first report of generalized ESDR triggered by amoxicillin in a paediatric patient. It emphasizes a unique pattern of drug hypersensitivity, characterized by cross\u2010reactivity to cefadroxil and tolerance to other tested penicillins (phenoxymethylpenicillin and oxacillin). It is essential to conduct a complete allergy work\u2010up, which includes OPTs, to conduct a customized cross\u2010reactivity assessment. This assessment is essential for the safe guidance of future therapeutic decisions in patients with drug\u2010induced ESDR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70495","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:44:56Z","timestamp":1771047896000},"page":"1929-1933","source":"Crossref","is-referenced-by-count":1,"title":["Amoxicillin\u2010induced Erythema Scarlatiniforme Desquamativum Recidivans with cross\u2010reactivity to cefadroxil in a child: A case report and review of literature"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4912-4461","authenticated-orcid":false,"given":"Hajer","family":"Bouraoui","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Fatouma Bourguiba University Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-1102","authenticated-orcid":false,"given":"Khadija","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Fatouma Bourguiba University Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Jemmeli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Taher Sfar University Hospital  Mahdia Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-5730","authenticated-orcid":false,"given":"Nesrine","family":"Ben\u2010Salah","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fattouma Bourguiba University Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Ben\u2010Mabrouk","sequence":"additional","affiliation":[{"name":"Department 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Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5828-8076","authenticated-orcid":false,"given":"Karim","family":"Aouam","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Fatouma Bourguiba University Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327678"},{"issue":"13","key":"e_1_2_7_3_1","first-page":"702","article-title":"Eryth\u00e8me scarlatiniforme desquamatif r\u00e9cidivant ou maladie de F\u00e9r\u00e9ol\u2010Besnier: Une entit\u00e9 peu connue","volume":"380","author":"Ferrara D","year":"2013","journal-title":"Rev Med 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