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This study aims to evaluate the protective effects of ALA on RIOM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized controlled study, 70 head and neck cancer (HNC) patients receiving definitive radiotherapy were assigned to receive either oral ALA (600\u2009mg twice daily) or placebo tablets throughout the radiotherapy period. The primary outcome was the assessment of the incidence and severity of RIOM using the Radiotherapy Oncology Group (RTOG) grading system. Secondary outcomes were the onset and duration of severe RIOM (Grades 3 and 4), quality of life (QOL), and serum total antioxidant capacity (TAC) and C\u2010reactive protein (CRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of severe RIOM was 16.7% with the use of ALA, while in the control group it was 41.3% (\n                      <jats:italic>p<\/jats:italic>\n                      value\u2009=\u20090.036). Moreover, ALA significantly delayed the occurrence of severe RIOM (\n                      <jats:italic>p<\/jats:italic>\n                      value\u2009=\u20090.033) and resulted in significantly shorter healing time (\n                      <jats:italic>p<\/jats:italic>\n                      value\u2009=\u20090.042). At the end of the study, ALA resulted in a mean percent change in QOL score from baseline of 43.33, which was non\u2010significantly different from the control group with a mean of 44.84. ALA significantly improved TAC levels but had no effect on CRP. The use of ALA was safe and tolerable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ALA showed a significant reduction in the severity and delayed the onset of RIOM with a high safety profile through its potent antioxidant effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70497","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:15:30Z","timestamp":1773137730000},"page":"2294-2304","source":"Crossref","is-referenced-by-count":2,"title":["Alpha\u2010lipoic acid as a preventive measure in radiation\u2010induced oral mucositis in head and neck cancer patients: A randomized controlled study"],"prefix":"10.1002","volume":"92","author":[{"given":"Beshoy Anwar","family":"Rizkalla","sequence":"first","affiliation":[{"name":"Clinical Pharmacy Department, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6278-6681","authenticated-orcid":false,"given":"Mohamed Reda","family":"Kelany","sequence":"additional","affiliation":[{"name":"Clinical Oncology Department, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-4853","authenticated-orcid":false,"given":"Nagwa Ali","family":"Sabri","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-2332","authenticated-orcid":false,"given":"May Ahmed","family":"Shawki","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864\u2010017\u20100484\u2010y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27725"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_5_1","unstructured":"MoawadM ShalabyMM SadeqMA et al.Insights into head and neck cancer research in Egypt: a scoping review. 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