{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:20:36Z","timestamp":1789410036022,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Individual second\u2010generation antihistamines may possess differential sedative potential due to the variability in central histamine receptor H1 occupancy. This study aimed to evaluate whether the sedative potential of second\u2010generation antihistamines is associated with the risk of injury during Japan's pollen season.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using data acquired from a nationwide health insurance claims database in Japan. We enrolled patients with allergic rhinitis who were newly prescribed oral second\u2010generation antihistamines during the pollen season (January\u2013May) between 2006 and 2022. Antihistamines were categorized into two groups based on the estimated central histamine receptor H1 occupancy: \u2265 10% (higher\u2010sedation group: cetirizine, levocetirizine, loratadine, olopatadine and bepotastine) and &lt; 10% (lower\u2010sedation group: fexofenadine, bilastine and desloratadine). The proportions of newly diagnosed injuries during the same pollen season were compared between the higher\u2010sedation and lower\u2010sedation groups using propensity score overlap weighting. Subgroup analysis that stratified patients by age (&lt; 65 and \u2265 65\u2009years) was also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1\u2009313\u2009550 eligible patients, 50.2% and 49.8% received higher\u2010sedation and lower\u2010sedation antihistamines, respectively. After overlap weighting, no significant difference in injury risk was observed between the groups (2.6%\n                      <jats:italic>vs<\/jats:italic>\n                      . 2.6%; risk difference, \u22120.0%; 95% confidence interval, \u22120.1 to 0.0; P\u2009=\u20090.388). Subgroup analysis showed consistent results across the age groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this large nationwide cohort of patients with allergic rhinitis, second\u2010generation antihistamines with higher\n                      <jats:italic>vs<\/jats:italic>\n                      . lower sedative potential showed no difference in injury risk during Japan's pollen season.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70505","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T04:09:21Z","timestamp":1771819761000},"page":"2230-2238","source":"Crossref","is-referenced-by-count":2,"title":["Risk of injury associated with the sedative potential of second\u2010generation antihistamines: A nationwide retrospective cohort 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health The University of Tokyo  Tokyo 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