{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:21:50Z","timestamp":1792070510214,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:p>\n                    Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) are fundamental in the management of type 2 diabetes mellitus (T2DM) and obesity. While early preclinical data raised concerns regarding direct pancreatic toxicity, contemporary human evidence from 2020 to 2025 has shifted the safety narrative. Meta\u2010analyses of randomized controlled trials (RCTs) demonstrate no statistically significant independent association between GLP\u20101 RA use and acute pancreatitis (AP) (MH\u2010OR 1.24 [0.94, 1.64];\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.13).However, real\u2010world data identifies a transient increase in risk during the first 6\u2009months of treatment (HR 1.340; 95% CI, 1.239\u20131.449;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.019). We propose that this \u2018pancreatic signal\u2019 is an indirect, biliary\u2010mediated phenomenon driven by rapid weight loss and drug\u2010induced gallbladder dysmotility via cholecystokinin (CCK) inhibition. Rather than restricting the indications of these cardioprotective therapies, clinical focus should pivot towards proactive biliary monitoring during the initial 24\u2009weeks of therapy.\n                  <\/jats:p>","DOI":"10.1002\/bcp.70512","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:36:32Z","timestamp":1772994992000},"source":"Crossref","is-referenced-by-count":4,"title":["The pancreatic signal of GLP\u20101 receptor agonists: A biliary phenomenon rather than direct toxicity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7586-1624","authenticated-orcid":false,"given":"Andro","family":"Koren","sequence":"first","affiliation":[{"name":"School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Koren","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724\u20106507.20.03219\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.70113"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"1","article-title":"GLP\u20101 receptor agonists and dual GLP\u20101\/GIP receptor agonists: strengthened warnings on acute pancreatitis, including necrotising and fatal cases","volume":"19","author":"Medicines and Healthcare products Regulatory Agency (MHRA)","year":"2026","journal-title":"Drug Saf Update"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14030944"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae260"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.92a.24113"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/20420188251406456"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v15.i4.95647"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2025.0242"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22\u20101148"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.81891"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2026.2620155"},{"key":"e_1_2_9_14_1","first-page":"S1","article-title":"The concise guide to pharmacology 2017\/2018: G protein\u2010coupled receptors","volume":"174","author":"Alexander SPH","year":"2017","journal-title":"Br J Pharmacol"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bcp.70512","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:36:33Z","timestamp":1772994993000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/bcp.70512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":13,"alternative-id":["10.1002\/bcp.70512"],"URL":"https:\/\/doi.org\/10.1002\/bcp.70512","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]},"article-number":"bcp.70512"}}