{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:35:36Z","timestamp":1787164536772,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Nausea and vomiting in pregnancy impact quality of life, yet many pregnant women feel dismissed by healthcare professionals, despite the safety of first\u2010line antiemetic treatments for both mother and fetus. Therefore, this study aims to describe the prevalence of patient\u2010reported antiemetic use in early pregnancy in Copenhagen, Denmark, the changes in use over two time periods, and the maternal characteristics of users and non\u2010users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed patient\u2010reported data on antiemetic use during early pregnancy and maternal characteristics from the Copenhagen Pregnancy Cohort (2012\u20132022). Descriptive statistics were applied to assess the prevalence, changes in use over two time periods and differences between users and non\u2010users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 40\u2009856 pregnancies, 1.0% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009412) reported using antiemetics in early pregnancy. Metoclopramide was the most used, reported by 0.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993). The number of pregnancies with patient\u2010reported antiemetic use doubled from 0.7% in 2012\u20132017 to 1.4% in 2018\u20132022. Among users, 83.3% received monotherapy, and 74.1% used antiemetics daily. Compared with non\u2010users, a significantly higher proportion of antiemetic users scored &lt;50 on the World Health Organization Five Well\u2010Being Index (66.6%\n                      <jats:italic>vs<\/jats:italic>\n                      . 20.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and to a higher extent reported sick leave (68.0%\n                      <jats:italic>vs<\/jats:italic>\n                      . 14.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found a low but rising prevalence of antiemetic use in early pregnancy, and the treatment often deviated from clinical guidelines. Antiemetic users differed from non\u2010users on several maternal characteristics, with a higher proportion reporting somatic and psychiatric disorders, as well as poorer mental well\u2010being, despite antiemetic treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70516","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T03:50:42Z","timestamp":1774237842000},"page":"2377-2389","source":"Crossref","is-referenced-by-count":1,"title":["Use of antiemetics in early pregnancy 2012\u20132022: A cross\u2010sectional study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5545-8117","authenticated-orcid":false,"given":"Katrine Bak","family":"Wraae","sequence":"first","affiliation":[{"name":"Department of Gynecology, Fertility and Obstetrics, Juliane Marie Centre Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"The Interdisciplinary Research Unit of Women's, Children's and Families' Health, The Juliane Marie Centre Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna Roed","family":"Ballegaard","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Fertility and Obstetrics, Juliane Marie Centre Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"The Interdisciplinary Research Unit of Women's, Children's and Families' Health, The Juliane Marie Centre Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie L\u00e6rkeholm","family":"Hede","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Fertility and Obstetrics, Juliane Marie Centre Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"The Interdisciplinary Research 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