{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:59:53Z","timestamp":1785373193967,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative opioids, intended for short\u2010term analgesia, contribute to new persistent opioid use in 1%\u20137% of patients, adversely affecting outcomes. Oxycodone may carry higher risk than morphine, though long\u2010term data are limited. This prospective comparative sequential cohort study assessed whether replacing from oxycodone with morphine as first\u2010line opioid after orthopaedic surgery affected new persistent opioid use at 6\u2009months and maintained analgesic equivalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients \u226518\u2009years undergoing orthopaedic surgery requiring \u22651 night hospitalization were enrolled April 2023 to January 2024. Primary outcome: new persistent opioid use at 6\u2009months, assessed by online survey. Secondary outcome: analgesic effectiveness assessed by pain at rest (NRS\u2009\u2265\u20094) at discharge and 6\u2009months, and daily opioid use (oral morphine equivalents) during hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 3675 eligible patients, 1894 (51.5%) completed the survey and were included (mean [SD] age 62.9 [13.1]\u00a0year; 62.5% female). Among these, 1021 were in the morphine first\u2010line opioid cohort and 873 in the oxycodone first\u2010line opioid cohort. The proportion of new persistent opioid use at 6\u2009months after surgery was 2.5% (morphine)\n                      <jats:italic>vs<\/jats:italic>\n                      . 2.6% (oxycodone) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.90). Pain at rest (NRS\u2009\u2265\u20094) was reported by 9.9%\n                      <jats:italic>vs<\/jats:italic>\n                      . 12.5% at discharge, and 19.3%\n                      <jats:italic>vs<\/jats:italic>\n                      . 19.7% at 6\u2009months (morphine\n                      <jats:italic>vs<\/jats:italic>\n                      . oxycodone). Median (IQR) daily opioid dose during hospitalization was 12.3 (0\u201330) and 15\u2009mg (0\u201330) (morphine\n                      <jats:italic>vs<\/jats:italic>\n                      . oxycodone). No significant differences were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Replacing oxycodone with morphine as first\u2010line opioid after orthopaedic surgery did not appear to reduce new persistent opioid use (NPOU) and provided comparable analgesia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70551","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:05:37Z","timestamp":1775293537000},"page":"2693-2700","source":"Crossref","is-referenced-by-count":0,"title":["Effect of oxycodone\n                    <i>vs<\/i>\n                    . morphine as first\u2010line opioid on new persistent opioid use after orthopaedic surgery: A prospective sequential cohort study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-3544","authenticated-orcid":false,"given":"Eward J.","family":"Melis","sequence":"first","affiliation":[{"name":"Department of Pharmacy Sint Maartenskliniek  Nijmegen The Netherlands"},{"name":"Department of Pharmacy Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna E.","family":"Vriezekolk","sequence":"additional","affiliation":[{"name":"Department of Research Sint Maartenskliniek  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique H. C.","family":"Bollen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Sint Maartenskliniek  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk E.","family":"Schrander","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sint Maartenskliniek  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnt F. A.","family":"Schellekens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"Nijmegen Institute for Scientist\u2010Practitioners in Addiction  Nijmegen The Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behavior Radboud University  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-9514","authenticated-orcid":false,"given":"Bart J. F.","family":"van den Bemt","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Sint Maartenskliniek  Nijmegen The Netherlands"},{"name":"Department of Pharmacy Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"Department of Research Sint Maartenskliniek  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16297"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7103a1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001430"},{"key":"e_1_2_12_5_1","unstructured":"Federatie Medisch Specialisten.Richtlijn Postoperatieve pijn. 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