{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:30Z","timestamp":1786977330599,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study compares sequential nephron blockade (SNB) and renin\u2013angiotensin system sequential blockade (RASSB) in patients with resistant hypertension (RHTN), evaluating central systolic pressure, arterial stiffness, pulse pressure and ambulatory blood pressure monitoring (ABPM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 72 patients with resistant hypertension were recruited from the Hypertension Outpatient Clinic and randomly allocated to two treatment groups: SNB (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200935; 22 women, 13 men) and RASSB (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200937; 22 women, 15 men). Central systolic blood pressure (CSBP), augmentation index (AI) and AI75 were assessed using validated non\u2010invasive tonometry. ABPM was performed over 24\u2009h to evaluate systolic, diastolic and pulse pressure changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Office blood pressure reductions were significant in both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u2009.0001). SNB: SBP from 174.5 to 127.0\u00a0mmHg; DBP from 105.3 to 78.11\u2009mmHg. RASSB: SBP from 178.4 to 134.4\u00a0mmHg; DBP from 102.7 to 77.33\u2009mmHg. ABPM confirmed 24\u2010h reductions (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u2009.0001). SNB showed greater pulse pressure reduction (\u0394\u2009=\u200922.99\n                      <jats:italic>vs<\/jats:italic>\n                      . 15.93\u2009mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.024) and central systolic pressure reduction (\u0394\u2009=\u2009\u221210.3\n                      <jats:italic>vs<\/jats:italic>\n                      . \u22125.1\u00a0mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.036). RASSB elicited a significant decrease in heart rate (\u0394\u2009=\u2009\u221212.4\u00a0bpm,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u2009.0001). No treatment\u2010related discontinuations occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SNB demonstrated superior efficacy in reducing CSBP and pulse pressure, while RASSB more effectively lowered heart rate. These distinct haemodynamic responses support individualized treatment strategies for patients with RHTN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70560","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:54:56Z","timestamp":1775638496000},"page":"2711-2722","source":"Crossref","is-referenced-by-count":2,"title":["Sequential nephron blockade\n                    <i>vs<\/i>\n                    . sequential renin\u2013angiotensin system blockade on central and ambulatory blood pressure in resistant hypertension: A randomized clinical trial"],"prefix":"10.1002","volume":"92","author":[{"given":"Juan Carlos","family":"Yugar\u2010Toledo","sequence":"first","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto (FAMERP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2008-9287","authenticated-orcid":false,"given":"Tatiana Palotta","family":"Minari","sequence":"additional","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto (FAMERP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla Galisteu","family":"de Mello","sequence":"additional","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto (FAMERP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"do Espirito Santo Cestario","sequence":"additional","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto (FAMERP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane","family":"de Azevedo Rubio","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences State University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Morete Caieiro","family":"da Costa","sequence":"additional","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto (FAMERP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Buonalumi T\u00e1cito","family":"Yugar","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences State University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Gustavo","family":"Sedenho\u2010Prado","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences State University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia Helena Bonalume","family":"Tacito","sequence":"additional","affiliation":[{"name":"Endocrinology Division of the Internal Medicine Department State Medical School of S\u00e3o Jos\u00e9 Rio Preto (FAMERP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Neves","family":"Cosenso\u2010Martin","sequence":"additional","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto (FAMERP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Fattori","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences State University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Pellegrini","family":"Pisani","sequence":"additional","affiliation":[{"name":"Department of Bioscience Federal University of S\u00e3o Paulo (UNIFESP)  Santos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Fernando","family":"Vilela\u2010Martin","sequence":"additional","affiliation":[{"name":"Hypertension Clinic, Department of Internal Medicine State Medical School of S\u00e3o Jos\u00e9 do Rio Preto (FAMERP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor","family":"Moreno","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences State University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000084"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010018\u20100825\u20107"},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","unstructured":"Yugar\u2010ToledoJC Moreno J\u00faniorH GusM et al. 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