{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:48:21Z","timestamp":1785412101163,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under\u2010reporting remains widespread. We tested a novel method to increase reporting of ADR\u2010related hospitalizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study used ADR\u2010indicative ICD\u201010 codes to screen admissions to four Swiss hospitals, identify suspected drugs and send individual case safety reports (ICSRs) of confirmed cases to Swissmedic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participating hospitals previously reported ~18 ICSRs annually. During the study period (7\/2023\u201312\/2023), 200 ADR\u2010related hospitalizations were reported following a review of 814 pre\u2010filtered admissions. Most ICSR data were available in structured format: Median age of patients was 59 (interquartile range [IQR] 42\u201375); 87 (44%) males; median of two comorbidities (IQR 1\u20133); the three most frequent ADRs were \u2018K52.1 Toxic gastroenteritis and colitis\u2019 (11 [6%]), \u2018T42.4 Poisoning by benzodiazepines\u2019 (10 [5%]) and \u2018R11 Nausea and vomiting\u2019 (10 [5%]). Discharge reports contained free\u2010text information on suspected drugs: More than half of ADR\u2010related hospitalizations were caused by antineoplastics (45 [23%]), psycholeptics (38 [19%]), opioids and other analgesics (34 [17%]). The median time to screen a case was 1\u2009min, 8\u2009min to collect, compile and send data of confirmed cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The approach successfully increased reporting of serious ADRs. The time investment for creating ICSRs might soon be rendered obsolete, as most data are available in structured format, and large language models are key to identifying suspected drugs in discharge reports.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70564","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:41:32Z","timestamp":1778046092000},"page":"2937-2948","source":"Crossref","is-referenced-by-count":2,"title":["Increasing the reporting of adverse drug reaction\u2010related hospitalizations using an ICD\u201010\u2010based identification workflow: A multicentre study from Switzerland"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9923-9821","authenticated-orcid":false,"given":"Georgia Anita","family":"Weber","sequence":"first","affiliation":[{"name":"Faculty for Health Sciences and Medicine University of Lucerne  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7441-2271","authenticated-orcid":false,"given":"Sophie\u2010Charlotte","family":"Bartel","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Lucerne Cantonal Hospital  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2510-3757","authenticated-orcid":false,"given":"Michael","family":"Boch","sequence":"additional","affiliation":[{"name":"Faculty for Health Sciences and Medicine University of Lucerne  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7087-4598","authenticated-orcid":false,"given":"Christoph","family":"Rosen","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy, Zug Cantonal Hospital  Baar Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bodmer","sequence":"additional","affiliation":[{"name":"Internal Medicine Zug Cantonal Hospital  Baar Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-1995","authenticated-orcid":false,"given":"Balthasar Luzius","family":"Hug","sequence":"additional","affiliation":[{"name":"Faculty for Health Sciences and Medicine University of Lucerne  Lucerne Switzerland"},{"name":"Center for Clinical Research Lucerne Cantonal Hospital\/University of Lucerne  Lucerne Switzerland"},{"name":"Internal Medicine Lucerne Cantonal Hospital, University Teaching and Research Hospital  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-3843","authenticated-orcid":false,"given":"Thomas","family":"Stammschulte","sequence":"additional","affiliation":[{"name":"Pharmacovigilance, Safety of Medicines Division, Swissmedic Swiss Agency for Therapeutic Products  Berne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6097-2480","authenticated-orcid":false,"given":"Patrick E.","family":"Beeler","sequence":"additional","affiliation":[{"name":"Faculty for Health Sciences and Medicine University of Lucerne  Lucerne Switzerland"},{"name":"Center for Clinical Research Lucerne Cantonal Hospital\/University of Lucerne  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010015\u20100281\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010023\u201001319\u2010y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0953\u20106205(01)00159\u20105"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2004.10801"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2118"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010018\u20102441\u20105"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010055551"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2021.20400"},{"key":"e_1_2_11_10_1","unstructured":"Swissmedic 2019 \u00a9 Copyright.Pharmacovigilance [Internet]. 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