{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:59:53Z","timestamp":1785373193084,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the association between Glucagon\u2010like peptide\u20101 receptor agonist (GLP\u20101RA) use and fracture risk in patients with or without chronic kidney disease (CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted using TriNetX, including patients aged 18\u201350. Two primary cohorts were defined: obese patients with CKD on GLP\u20101RAs\u2009\u2265\u20091\u00a0year (CKD+\/GLP\u20101RA+) and obese patients with CKD not on GLP\u20101RAs (CKD+\/GLP\u20101RA\u2010). A subgroup analysis compared CKD+\/GLP\u20101RA\u2009+\u2009patients to obese patients without CKD on GLP\u20101RAs (CKD\u2010\/GLP\u20101RA+). Primary outcomes were upper and lower limb fractures. Risk analysis and Kaplan\u2013Meier survival analysis assessed fracture incidence over 5\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, 13\u2009441 patients were included per cohort. CKD+\/GLP\u20101RA\u2009+\u2009patients had fewer fractures than CKD+\/GLP\u20101RA\u2010 patients (Risk Difference: \u20100.016, 95% CI: \u22120.018, \u22120.013; RR: 0.196, 95% CI: 0.145, 0.265; OR: 0.193, 95% CI: 0.143, 0.261), with higher fracture\u2010free survival (99.31%\n                      <jats:italic>vs<\/jats:italic>\n                      . 95.47%; p\u2009&lt;\u20090.001). Subgroup analysis (13\u2009723 patients per cohort) showed CKD+\/GLP\u20101RA\u2009+\u2009patients had a slightly higher fracture risk than CKD\u2010\/GLP\u20101RA\u2009+\u2009patients (Risk Difference: 0.003, 95% Cl: 0.001, 0.004; RR: 2.357, 95% Cl: 1.516, 3.665; OR: 2.364, 95% Cl: 1.518, 3.680), with lower fracture\u2010free survival (98.87%\n                      <jats:italic>vs<\/jats:italic>\n                      . 99.19%; p\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest a possible CKD\u2010associated modification on the skeletal effects of GLP\u20101RAs, implicating that CKD patients' bone health should be monitored during GLP\u20101RA treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70566","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:27:44Z","timestamp":1776432464000},"page":"2788-2796","source":"Crossref","is-referenced-by-count":1,"title":["The interplay of GLP\u20101 receptor agonist use, chronic kidney disease and fracture risk in obese pAtients: a retrospective cohort study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0797-4931","authenticated-orcid":false,"given":"Amari","family":"Eubanks","sequence":"first","affiliation":[{"name":"Howard University College of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1182-5749","authenticated-orcid":false,"given":"Kiana C.","family":"Allen","sequence":"additional","affiliation":[{"name":"Howard University College of Medicine  Washington DC 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Medicine Howard University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1337-9168","authenticated-orcid":false,"given":"Damon","family":"Ross","sequence":"additional","affiliation":[{"name":"Howard University College of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Beyene","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekdem","family":"Bisrat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Fahad","family":"Gillani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Howard University  Washington 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