{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:59:54Z","timestamp":1785373194576,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>A prior non\u2010randomized study suggests that potassium supplementation may improve survival among furosemide initiators, and a randomized trial suggests that salt substitutes containing potassium might lower stroke risk. We conducted a retrospective cohort study using health\u2010care data to confirm or refute these associations among new users of furosemide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The exposure of interest was empiric potassium dispensing (yes\/no) concurrent with furosemide initiation. Outcomes were all\u2010cause mortality, sudden cardiac arrest\/ventricular arrhythmia (SCA\/VA), and stroke. Primary as\u2010started and secondary as\u2010treated analyses were performed with Cox proportional hazards regression. We used inverse probability of treatment weighting (IPTW) to control for confounding, with weights calculated from high\u2010dimensional propensity scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 511\u2009462 and 320\u2009703 initiators of furosemide &lt;40 and \u226540\u2009mg\/day with 21.5% and 35.3%, respectively, starting empiric potassium supplementation. In initiators of furosemide &lt;40\u2009mg\/day with (\n                      <jats:italic>vs<\/jats:italic>\n                      . without) empiric potassium, as\u2010started IPTW\u2010hazard ratios (HRs) were 1.02 (95%CI 1.01\u20131.04) for death, 1.00 (0.94\u20131.04) for SCA\/VA, and 1.03 (1.00\u20131.06) for stroke. Similarly, in initiators of furosemide \u226540\u2009mg\/day with (\n                      <jats:italic>vs<\/jats:italic>\n                      . without) empiric potassium, as\u2010started IPTW\u2010HRs were 1.02 (1.00\u20131.03) for death, 0.98 (0.94\u20131.03) for SCA\/VA, and 1.01 (0.98\u20131.04) for stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We did not observe associations suggesting a clinically meaningful effect of empiric potassium supplementation among furosemide users. However, given the high prevalence of furosemide use among highly heterogeneous patient populations, a large pragmatic trial may be warranted to more definitively evaluate the potential benefits and harms of empiric potassium supplementation among furosemide initiators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70584","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:30:26Z","timestamp":1777869026000},"page":"2924-2936","source":"Crossref","is-referenced-by-count":0,"title":["Impact of empiric potassium supplementation on mortality, sudden cardiac arrest and stroke in furosemide initiators"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-764X","authenticated-orcid":false,"given":"Thanh Phuong","family":"Pham Nguyen","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Department of Neurology Translational Center for Excellence for Neuroepidemiology and Neurological Outcomes Research University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Center for Real\u2010World Effectiveness and Safety of Therapeutics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Hennessy","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Center for Real\u2010World Effectiveness and Safety of Therapeutics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania 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B.","family":"Bilker","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Center for Real\u2010World Effectiveness and Safety of Therapeutics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Dember","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Renal\u2010Electrolyte and Hypertension Division, Department of Medicine University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-6212","authenticated-orcid":false,"given":"Todd A.","family":"Miano","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Center for Real\u2010World Effectiveness and Safety of Therapeutics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tat\u2010Thang","family":"Vo","sequence":"additional","affiliation":[{"name":"Department of Statistics and Data Science, The 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