{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:16:10Z","timestamp":1778066170695,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000035","name":"Institute of Nutrition, Metabolism and Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation. Accordingly, there is a need for predictive or early diagnostic biomarkers for cisplatin\u2010induced nephrotoxicity that help determine AKI risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Samples from the Applying Biomarkers to Long\u2010term Effects in Child and Adolescent Cancer Treatment (ABLE) study were used. Urine and serum from 86 patients were subjected to an exploratory untargeted metabolomics analysis. Urine and serum samples were collected prior to cisplatin, 24\u201348\u2009h after cisplatin and 5\u201314\u2009days after cisplatin. Liquid chromatography\u2013mass spectrometry\u2010based metabolomics was performed on serum and urine to identify predictive or early diagnostic biomarkers of cisplatin\u2010induced AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 86 patients included in this study, 34\/86 (39.5%) were classified as having AKI based on SCr change from baseline. Overall, there was poor metabolomic discrimination of AKI\n                      <jats:italic>vs<\/jats:italic>\n                      . no\u2010AKI. When patients were stratified by age (\u22643\n                      <jats:italic>vs<\/jats:italic>\n                      . &gt;3\u00a0years old), discrimination was greatly improved. Urinary metabolites of the NAD+ synthesis pathway (kynurenine, 2\u2010PY, 1\u2010methlynicotinamide and quinolinate) were found to be significantly elevated in AKI patients compared to no\u2010AKI patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Urine metabolomic differences exist 24\u201348\u2009h following cisplatin dosing in paediatric patients who develop AKI. Changes in metabolites involved in the NAD+ synthesis pathway may serve as early indicators of cisplatin\u2010induced nephrotoxicity and may represent promising therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70587","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T10:48:32Z","timestamp":1778064512000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolomic investigation of cisplatin\u2010induced acute kidney injury in paediatric cancer patients"],"prefix":"10.1002","author":[{"given":"Yong Jin","family":"Lim","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Thachil","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics British Columbia Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Nephrology Research Institute of the McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross T.","family":"Tsuyuki","sequence":"additional","affiliation":[{"name":"Epicore Center, Department of Medicine, Department of Pharmacology University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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D.","family":"Ross","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra P.","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Children's Hospital London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Baruchel","sequence":"additional","affiliation":[{"name":"Translational Medicine, The Hospital for Sick Children Research Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raveena","family":"Ramphal","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics Children's Hospital of Eastern Ontario\u2010Ottawa Children's Treatment Centre  Ottawa Ontario 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