{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:19:51Z","timestamp":1787822391211,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Dexmedetomidine (DEX) seems to hold a potential neuroprotective role, possibly mediated by the attenuation of oxidative stress and neuroinflammation. This study aimed to delineate the effect of DEX used as an adjunct anaesthetic on cerebral oxygenation, cerebral injury and the release of inflammatory markers in brain tumour surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010six patients undergoing craniotomy for brain tumour excision were randomly assigned to receive either DEX (1\u2009\u03bcg\/kg for 10\u00a0min and thereafter 0.7\u00a0\u03bcg\/kg\/h) or placebo. Arterial and jugular\u2010bulb blood samples were collected at predefined time\u2010points, whereas a concomitant hemodynamic profile was obtained intraoperatively. S100B protein, neuron\u2010specific enolase (NSE), tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106) and cortisol levels were determined at baseline and 6 and 24\u2009h postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Demographic and perioperative characteristics were comparable between groups. Propofol consumption was considerably reduced in DEX\u2010treated patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Measured (jugular\u2010bulb oxygen saturation and partial pressure of oxygen) and estimated (oxygen and carbon dioxide arterial\u2010jugular differences, brain oxygen extraction ratio) cerebral oxygenation indices were favourably affected by DEX infusion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), yet this effect was valid for 15\u2009min (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), corresponding to transient systemic hemodynamic augmentation. Moreover, postoperative S100B, NSE, TNF\u2010\u03b1, IL\u20106 and cortisol levels were significantly attenuated in the DEX group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DEX may attenuate the release of cerebral injury and neuroinflammation biomarkers and transiently improve hemodynamics and cerebral oxygenation during brain tumour surgery. Nonetheless, these surrogate effects do not establish clinically relevant neuroprotection, and potential dose\u2010related hemodynamic instability warrants cautious, individualized use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70606","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:15:13Z","timestamp":1778289313000},"page":"3071-3081","source":"Crossref","is-referenced-by-count":0,"title":["Effect of dexmedetomidine on cerebral homeostasis in patients undergoing craniotomy for brain tumour excision: A randomized double\u2010blind trial"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3938-8719","authenticated-orcid":false,"given":"Anastasia","family":"Nikopoulou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Aristotle University of Thessaloniki, School of Medicine  Thessaloniki 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University of Thessaloniki, School of Medicine  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Patsalas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Aristotle University of Thessaloniki, School of Medicine  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia G.","family":"Tsaousi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Aristotle University of Thessaloniki, School of Medicine  Thessaloniki 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