{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:08:44Z","timestamp":1784099324114,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n Atopic dermatitis (AD) is a chronic immune\u2010mediated inflammatory skin disease. An overgrowth of\n \n Staphylococcus aureus<\/jats:styled-content>\n (\n S. aureus<\/jats:styled-content>\n )\n <\/jats:italic>\n and decreased microbial diversity is apparent in 70%\u201390% of AD patients. SA.100 is a recombinant endolysin targeting\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n that might be a novel treatment for patients with mild\u2010to\u2010moderate AD. To test safety, pharmacodynamics and efficacy of SA.100 a double\u2010blind, randomized, vehicle\u2010controlled trial in 53 subjects with mild\u2010to\u2010moderate AD was performed. Patients were randomized equally to topical SA.100 or vehicle with stratification for\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n positivity. SA.100 was safe and well tolerated. No reduction of\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n and no changes in microbiome features were seen after 2\u2009weeks of treatment. Additionally, no statistically significant changes in clinical or patient\u2010reported outcomes were observed compared to vehicle. In conclusion, topical SA.100 was safe and well tolerated in patients with mild\u2010to\u2010moderate AD, but our findings do not support short\u2010term clinical use.\n <\/jats:p>","DOI":"10.1002\/bcp.70608","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:05:42Z","timestamp":1778551542000},"page":"2409-2413","source":"Crossref","is-referenced-by-count":1,"title":["Lack of improvement after short\u2010term topical antistaphylococcal endolysin SA.100 therapy in patients with mild\u2010to\u2010moderate atopic dermatitis: Results from a randomized, vehicle\u2010controlled trial"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7329-0080","authenticated-orcid":false,"given":"Laura W. J.","family":"van der Meulen","sequence":"first","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"},{"name":"Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menthe E.","family":"Bergmans","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"},{"name":"Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Assil","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"},{"name":"Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismahaan","family":"Abdisalaam","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"},{"name":"Leiden University Medical Centre Leiden The Netherlands"},{"name":"Department of Dermatology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne","family":"Rijneveld","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"},{"name":"Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa J.","family":"Tibboel","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Brach","sequence":"additional","affiliation":[{"name":"Clinical Microbiomics Clinical Microbiomics A\/S Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn L.","family":"Herpers","sequence":"additional","affiliation":[{"name":"Regional Public Health Laboratory Kennemerland Haarlem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Frieling","sequence":"additional","affiliation":[{"name":"Micreos Human Health Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benthe","family":"Freyee","sequence":"additional","affiliation":[{"name":"Micreos Human Health Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Platenkamp","sequence":"additional","affiliation":[{"name":"Micreos Human Health Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariette E.","family":"van Poelgeest","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"},{"name":"Department of Gynecology and Obstetrics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5867-9090","authenticated-orcid":false,"given":"Robert","family":"Rissmann","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"},{"name":"Leiden University Medical Centre Leiden The Netherlands"},{"name":"Leiden Amsterdam Center for Drug Research Leiden University Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn B. 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