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Two hundred one cases (43% women, 91% Swedish) were compared with 4891 Swedish population controls. Analyses were performed on two candidate variants in coagulation factor II (rs1799963) and coagulation factor V (rs6025), on 14 prespecified candidate genes and across the whole genome. To support the findings, we conducted an observational register study of the Swedish general population with\/without a diagnosis of thrombophilia and the risks of venous thromboembolism after SARS\u2010CoV\u20102 vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the GWAS, the main findings were that the candidate variants of coagulation factors II rs1799963 and V rs6025 were significantly associated with venous thromboembolism (odds ratio [OR] 2.4 [95% confidence interval (CI) 1.2\u20134.8],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.015 and OR 1.8 [95% CI 1.3\u20132.6],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0022). No genetic marker passed the significance threshold in the candidate gene analysis or the full genome\u2010wide analysis. In the register study, people with a thrombophilia diagnosis had a five\u2010fold elevated risk of venous thromboembolism within 42\u2009days after vaccination, adjusted for potential confounders, OR 5.06 [95% CI 3.98\u20136.44].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Well\u2010characterized genetic variants in the genes of coagulation factors II and V were associated with thromboembolism after SARS\u2010CoV\u20102 immunization. Further research is recommended to elucidate their potential role in vaccine\u2010related thromboembolic events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70614","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:15:38Z","timestamp":1779952538000},"page":"3246-3256","source":"Crossref","is-referenced-by-count":0,"title":["Risk of venous thromboembolism after SARS\u2010CoV\u20102 vaccination\u2014Evidence from genome\u2010wide association study and population\u2010based observational study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-7376","authenticated-orcid":false,"given":"Sofia","family":"Attelind","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Clinical Pharmacogenomics Uppsala University  Uppsala Sweden"},{"name":"Department of Drug Safety Swedish Medical Products Agency  Uppsala 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