{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:19:54Z","timestamp":1787822394058,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>By age three, 5%\u201375% of children have a documented antibiotic allergy (AL). Despite this prevalence, recognition remains low because of limited clinician knowledge and time. Our study evaluates a novel approach to identifying AL using electronic medical record (EMR) prescription patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An EMR report was developed to identify paediatric encounters where adrenaline and\/or an antihistamine was administered within 48\u2009h of the last antibiotic dose. The first 100 cases were reviewed to refine exclusion criteria. Exclusions included diagnoses of eczema, or rash; antihistamine\/adrenaline given before antibiotic initiation; adrenaline infusion; and antihistamines given after opioids or before blood products or monoclonal antibodies. Case notes from the cohort (2016\u20132023) were reviewed for suspected AL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The EMR report identified 342 children, with 67 (20%) assessed as having a possible\/probable AL. Of these, 38 (57%) had a documented allergy, whereas 29 (43%) were newly identified. Implicated antimicrobials were ceftriaxone (34%), flucloxacillin (19%) and amoxicillin\u2009\u00b1\u2009clavulanic acid (18%). Immediate\u2010severe reactions accounted for eight cases (12%), including anaphylaxis (9%), angioedema (1%) and respiratory distress (1%). Most reactions (82%) were nonimmediate, nonsevere reactions. One case (1%) was a nonimmediate, severe, serum\u2010sickness\u2010like reaction. Of the 29 newly identified cases, six (21%) were considered too high of a risk to undergo antibiotic challenge, and three (13%) had a positive challenge result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study using EMR prescription patterns to identify AL in children. One in five children had a potential AL. This method could complement existing allergy identification practices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70618","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:42:09Z","timestamp":1779284529000},"page":"3161-3168","source":"Crossref","is-referenced-by-count":0,"title":["Identification of antibiotic allergies in children using prescribing patterns in the electronic medical record"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0550-7861","authenticated-orcid":false,"given":"Georgia","family":"Koutsaplis","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Royal Children's Hospital Melbourne  Parkville Victoria Australia"},{"name":"Antimicrobials Group Murdoch Children's Research Institute  Parkville Victoria 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