{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:19:49Z","timestamp":1787822389752,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The superiority of colloids over crystalloids for volume resuscitation remains uncertain despite theoretical advantages in intravascular expansion. We hypothesized that distinct myocardial mechanical responses may explain this discrepancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010centre, double\u2010blind, randomized crossover trial, participants received sequential 500\u2010 and 1000\u2010mL infusions of either Gelafundin 4% (colloid) or 0.9% sodium chloride (crystalloid), with a 7\u2010day washout before crossover. Left ventricular global longitudinal strain (GLS), torsion (TOR), left atrial strain (LAS) and right ventricular (RV) free wall strain curves were acquired by speckle\u2010tracking echocardiography. Functional data analysis was applied to entire strain curves to detect time\u2010specific differences across the cardiac cycle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty healthy volunteers were enrolled (mean age 27.2\u2009\u00b1\u20094.3\u00a0years; 20% women). Conventional echocardiographic and hemodynamic parameters remained comparable across groups. GLS differed significantly between fluids around end\u2010systole (maximum difference \u22121%), favouring colloids. RV strain showed significant between\u2010fluid differences primarily during diastole (maximum difference +2%). LV torsion increased significantly with colloid (maximum difference +3%), with a fluid\u2010specific response during untwist. LAS exhibited the largest between\u2010group differences at both infusion volumes (maximum difference +6%), and within\u2010group analysis revealed distinct phase\u2010specific adaptations, predominantly affecting LA phasic function and LV twist\u2013untwist dynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Volume loading produces changes in GLS and RV longitudinal strain that are similar in pattern but greater in amplitude, favouring colloids, whereas twist mechanics and left atrial reservoir and conduit function exhibit distinct, volume\u2010dependent and fluid\u2010modulated myocardial deformation patterns.<\/jats:p>\n                  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