{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:20:35Z","timestamp":1790630435371,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The TEN\u2010SPIDERS framework provides a structured approach to calculating and reporting the proportion of days covered (PDC) in medication adherence research, but gaps remain in operationalizing this framework into statistical code. We aimed to develop an open\u2010source tool to standardize PDC calculation against parameters of the TEN\u2010SPIDERS reporting framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Phase 1 involved developing the Stata statistical tool to enable flexible adjustment of TEN\u2010SPIDERS PDC parameters: threshold, eligibility, numerator, in\u2010hospital stays, dose imputation, early refills and survival. The tool was developed to align with established data definitions, variable schemas and person\u2010level record structures in linked Australian Pharmaceutical Benefits Scheme (PBS) datasets, with scope for interoperability across similar international systems. In Phase 2, PDC was estimated in a linked PBS dataset for survivors of myocardial infarction (37\u2009919 statin users and 29\u2009163 P2Y12 inhibitor users). The impact of different TEN\u2010SPIDERS adjustments was evaluated against basic settings and a pre\u2010existing Stata package (MedAdhere).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The TEN\u2010SPIDERS tool was developed to support reproducible PDC calculations. While computation time was similar to the pre\u2010existing MedAdhere package (116.5\n                      <jats:italic>vs<\/jats:italic>\n                      . 100.2\u2009s), the TEN\u2010SPIDERS tool had greater flexibility to incorporate adjustments for different medication\u2010taking situations. A bivariate comparison between different settings of TEN\u2010SPIDERS highlighted a strong correlation (Pearson's\n                      <jats:italic>r<\/jats:italic>\n                      : &gt;.9) with MedAdhere, with additional adjustments reducing Pearson's correlation from .987 to .921.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The TEN\u2010SPIDERS tool provides a transparent, reproducible and efficient open\u2010source method for medication adherence research within Australia, with potential applicability to similarly structured international datasets. Adoption of this tool will support global efforts for standardization in medication adherence research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70646","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:23:16Z","timestamp":1783354996000},"source":"Crossref","is-referenced-by-count":1,"title":["Standardization of measurement and reporting of medication adherence using the TEN\u2010SPIDERS tool for claims data"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5337-8061","authenticated-orcid":false,"given":"Adam C.","family":"Livori","sequence":"first","affiliation":[{"name":"Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical, Sciences Monash University  Melbourne Victoria Australia"},{"name":"Pharmacy Department Grampians Health  Ballarat Victoria Australia"},{"name":"Clinical Diabetes and Epidemiology Baker Heart and Diabetes Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2511-1123","authenticated-orcid":false,"given":"Tzu\u2010Yung","family":"Kuo","sequence":"additional","affiliation":[{"name":"Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences Monash University  Melbourne Victoria Australia"},{"name":"Victorian Heart Institute Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0348-9441","authenticated-orcid":false,"given":"Jenni","family":"Ilom\u00e4ki","sequence":"additional","affiliation":[{"name":"Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical, Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3375-287X","authenticated-orcid":false,"given":"Monique F.","family":"Kilkenny","sequence":"additional","affiliation":[{"name":"Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences Monash University  Melbourne Victoria Australia"},{"name":"Victorian Heart Institute Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7739-3381","authenticated-orcid":false,"given":"Stella","family":"Talic","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-3963","authenticated-orcid":false,"given":"Zanfina","family":"Ademi","sequence":"additional","affiliation":[{"name":"Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical, Sciences Monash University  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Simon","family":"Bell","sequence":"additional","affiliation":[{"name":"Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical, Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-5758","authenticated-orcid":false,"given":"Jedidiah I.","family":"Morton","sequence":"additional","affiliation":[{"name":"Clinical Diabetes and Epidemiology Baker Heart and Diabetes Institute  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1449-9132","authenticated-orcid":false,"given":"Lachlan L.","family":"Dalli","sequence":"additional","affiliation":[{"name":"Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences Monash University  Melbourne Victoria Australia"},{"name":"Victorian Heart Institute Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14796678.2024.2433888"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010023\u201000972\u20101"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14024"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3756"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2021.04.023"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/PDS.5776"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15391"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1177\/1060028016634106","article-title":"Proposal of Standardization to Assess Adherence With Medication Records: Methodology Matters","volume":"50","author":"Arnet I","year":"2016","journal-title":"Ann Pharmacother"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5567"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X19893625"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad360"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2024.04.307"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19883"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2331"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201019425\u20107"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.16042"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70003"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/MLR.0b013e3182984c1f","article-title":"Group\u2010based trajectory models: a new approach to classifying and predicting long\u2010term medication adherence","volume":"51","author":"Franklin JM","year":"2013","journal-title":"Med Care"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.1608"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.121.008335"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac015"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14468"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2025.105847"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bcp.70646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:23:17Z","timestamp":1783354997000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/bcp.70646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":23,"alternative-id":["10.1002\/bcp.70646"],"URL":"https:\/\/doi.org\/10.1002\/bcp.70646","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"article-number":"bcp.70646"}}