{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:57:29Z","timestamp":1790621849065,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study investigates the association between amyloid\u2010\u03b2 (A\u03b2) biomarkers and clinical cognitive outcomes and quantitatively elucidates their relationship, providing robust evidence supporting the amyloid hypothesis and advancing the development of novel anti\u2010amyloid therapeutics, such as aducanumab, lecanemab and donanemab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Placebo\u2010controlled randomized clinical trials reporting A\u03b2\u2010related biomarkers and cognitive function clinical outcomes were retrieved from PubMed, EMBASE and Cochrane Library. Pearson correlation analysis was first used to screen indices, and then a model\u2010based meta\u2010analysis (MBMA) using non\u2010linear mixed\u2010effect modelling was established to predict cognitive function based on biomarkers while examining relevant factors affecting the relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Primary outcomes included changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR\u2010SB) and the Alzheimer's Disease Assessment Scale\u2013Cognitive Subscale (ADAS\u2010COG\u201011). The analysis included 57 articles representing 93\u2009417 subjects, with a modelling subset of 18\u2009246 patients providing paired biomarker\u2010endpoint data for Alzheimer's disease or mild cognitive impairment. Results showed significant correlations between the standard uptake value ratio (SUVR) of \u03b2\u2010amyloid plaques and CDR\u2010SB, centiloid and CDR\u2010SB, and SUVR and ADAS\u2010COG\u201011. Three prediction models of cognitive function scales based on imaging index of \u03b2\u2010amyloid plaques were established and found to be significantly impacted by factors such as baseline CDR\u2010SB, treatment duration and the proportion of patients receiving basic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study clarified the correlation and established predictive models for CDR\u2010SB and ADAS\u2010COG\u201011 based on amyloid imaging. This research identifies potential biomarkers and model\u2010derived benchmarks for future dose selection and decision\u2010making in Alzheimer's drug development, potentially accelerating the development of new treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70665","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:44:17Z","timestamp":1782708257000},"page":"3576-3585","source":"Crossref","is-referenced-by-count":1,"title":["Predicting cognitive function in Alzheimer's clinical trials via amyloid \u03b2\u2010protein biomarkers"],"prefix":"10.1002","volume":"92","author":[{"given":"Zichao","family":"Sui","sequence":"first","affiliation":[{"name":"Center for Drug of Clinical Research Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aobo","family":"Feng","sequence":"additional","affiliation":[{"name":"Center for Drug of Clinical Research 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