{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:00:16Z","timestamp":1790622016287,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Anti\u2010seizure medications (ASMs) are in the list of the most common drug culprits of drug reaction with eosinophilia and systemic symptoms (DRESS). However, no study has systematically evaluated DRESS associated with ASMs in a large paediatric cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>This study aimed to investigate association of DRESS with ASMs and to characterize the onset pattern of ASM\u2010related DRESS in paediatrics using FDA Adverse Event Report System (FAERS) database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>FAERS data from the first quarter of 2004 to the second quarter of 2025 were analysed using R software (version 4.5.1). For signal detection of ASM\u2010related DRESS in paediatric patients, disproportionality analysis was performed with four methods, consisting of Reporting Odds Ratio, Proportional Reporting Ratio, Bayesian Confidence Propagation Neural Network and Multi\u2010Item Gamma Poisson Shrinker. Cumulative incidence was estimated using Kaplan\u2013Meier method, and time\u2010to\u2010onset (TTO) analysis was conducted with Weibull distribution test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine hundred forty\u2010one reports of ASMs\u2010related DRESS in paediatric population from FAERS database were analysed. Positive signals for DRESS were identified for lamotrigine, carbamazepine, levetiracetam, phenytoin, valproic acid, oxcarbazepine, phenobarbital, zonisamide, clobazam, ethosuximide, perampanel, fosphenytoin and eslicarbazepine. Ninety\u2010eight cases were included in the TTO analysis. Lamotrigine, carbamazepine, levetiracetam and zonisamide demonstrated a wear\u2010out failure\u2010type pattern. Phenytoin, valproic acid and oxcarbazepine presented a random failure\u2010type profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Significant signals of DRESS associated with 13 ASMs were identified in paediatric populations. Notably, signals were detected for the first time for ethosuximide, perampanel, fosphenytoin and eslicarbazepine by disproportionality analysis. TTO analysis demonstrated wear\u2010out or random failure\u2010type patterns in the occurrence of ASM\u2010associated DRESS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70677","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:16:20Z","timestamp":1783088180000},"page":"3676-3686","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time\u2010to\u2010onset analysis"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6187-2467","authenticated-orcid":false,"given":"Ting","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyue","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9296-1873","authenticated-orcid":false,"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2005.66104.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3908"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368801"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000712"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00613"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000715"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.02.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)30378\u20106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.02.072"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.02.073"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.03.081"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14044"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14446"},{"key":"e_1_2_10_15_1","unstructured":"FDA warns of rare but serious drug reaction to the antiseizure medicines levetiracetam (Keppra Keppra XR Elepsia XR Spritam) and clobazam (Onfi Sympazan). 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