{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:18:15Z","timestamp":1783397895548,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Corticosteroids have side effects like adrenal insufficiency (AI) and bone decalcification, amongst others. Swallowed formulations appear to be les harmful. Our aim is to study the effects of orodispersable budesonide used in patients with eosinophilic esophagitis (EoE) on the hypothalamic\u2010pituitary\u2010adrenal axis, by using a test with higher sensitivity than measuring basal cortisol levels, and on bone resorption and formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective study with 20 patients with confirmed diagnosis of EoE, with no previous response to proton pump inhibitors (PPI) and no previous treatment with corticosteroids. They were given orodispersable budesonide tablets (OBT) 1\u00a0mg twice a day for 14\u2009weeks. They were carried out physical exams, blood tests and an adrenocorticotropic hormone (ACTH) stimulation test before and after the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Differences in Synacthen test before and after treatment with OBT were not statistically significant, with only three patients below the baseline of 18\u2009mcg\/dL of cortisol 60\u2009min after the administration of ACTH in the second visit. A statistically significant decrease in seric osteocalcin and bone alkaline phosphatase (BAP) was found, while other bone resorption values remained unchanged after the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study endorses that adult patients with EoE in treatment with OBT have no risk of AI, which might simplify their management. Osteocalcin and BAP decrease could reveal corticoids systemic absorption, although its clinical relevance needs to be determined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70678","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:58:24Z","timestamp":1783396704000},"source":"Crossref","is-referenced-by-count":0,"title":["Safety of swallowed corticosteroids and their influence on the hypothalamic\u2013pituitary\u2013adrenal gland axis and on markers of bone resorption and formation in patients with eosinophilic esophagitis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3775-1481","authenticated-orcid":false,"given":"Jes\u00fas","family":"S\u00e1nchez C\u00e9sar","sequence":"first","affiliation":[{"name":"Gastroenterology Unit Hospital Cl\u00ednico San Carlos; IdISSC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-8956","authenticated-orcid":false,"given":"Valent\u00edn","family":"Roales G\u00f3mez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Hospital Cl\u00ednico San Carlos; IdISSC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-7104","authenticated-orcid":false,"given":"Mart\u00edn","family":"Cuesta Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"L\u00f3pez Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Hospital Cl\u00ednico San Carlos; IdISSC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-1881","authenticated-orcid":false,"given":"Constanza","family":"Ciriza de los R\u00edos","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Hospital Cl\u00ednico San Carlos; IdISSC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Mendoza Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Hospital Cl\u00ednico San Carlos; 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