{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:58:16Z","timestamp":1790621896024,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Psilocybin shows potential in neuropsychiatric disorders but has a complex relationship with epilepsy and seizures. We reviewed literature up to November 2025 to identify studies relevant to psilocybin's effects on seizures and epilepsy, including our research on serotonergic modulation. Core studies addressing the research question and supplementary mechanistic evidence were included for synthesis. Risk of bias (RoB) was assessed by study type; independent reviewers achieved strong agreement (unweighted Cohen's\n                    <jats:italic>\u03ba<\/jats:italic>\n                    \u2009=\u20090.80, SE\u2009=\u20090.185; 99% CI 0.006\u20130.011; per cent agreement\u2009=\u200988.9%). Experimental models suggest\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.guidetopharmacology.org\/GRAC\/LigandDisplayForward?ligandId=14389\">psilocybin<\/jats:ext-link>\n                    , through 5\u2010hydroxytryptamine receptor 2A (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=6\">5-T2A<\/jats:ext-link>\n                    ) activation, may confer antiseizure effects. Preclinical data support serotonergic modulation as a promising strategy. RoB assessment highlighted methodological challenges, suggesting cautious interpretation. Clinical evidence in neuropsychiatric populations shows no increased seizure risk under medical supervision. Psilocybin could serve as an adjunctive therapy via selective serotonergic modulation. However, conflicting evidence and concerns at high doses urge caution. Future animal studies and clinical trials must confirm psilocybin's safety and efficacy in the treatment of epilepsy.\n                  <\/jats:p>","DOI":"10.1002\/bcp.70690","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:24:22Z","timestamp":1784697862000},"page":"3316-3332","source":"Crossref","is-referenced-by-count":0,"title":["Psilocybin as serotonergic therapy in epilepsy: Narrative review of potentials and limitations"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-121X","authenticated-orcid":false,"given":"Miguel Benjamin","family":"Cervera\u2010Sanchez","sequence":"first","affiliation":[{"name":"Epilepsy Clinic National Institute of Neurology and Neurosurgery  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6685-5851","authenticated-orcid":false,"given":"Daniel","family":"San\u2010Juan","sequence":"additional","affiliation":[{"name":"Epilepsy Clinic National Institute of Neurology and Neurosurgery  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-2874","authenticated-orcid":false,"given":"Roberto","family":"D\u00edaz\u2010Peregrino","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Heidelberg University Hospital Ruprecht Karls University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0122-9032","authenticated-orcid":false,"given":"Evelin Zulema","family":"Camacho\u2010Castillo","sequence":"additional","affiliation":[{"name":"Epilepsy Clinic National Institute of Neurology and Neurosurgery  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0072-9384","authenticated-orcid":false,"given":"Sthefany Anahi","family":"Bringas\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Autonomous University of Mexico State  Toluca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6948-783X","authenticated-orcid":false,"given":"Christian","family":"Padilla\u2010Cabezutd","sequence":"additional","affiliation":[{"name":"University Center for Health Science University of Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010026\u201004287\u20109"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00046"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010013\u20103757\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12580"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.04.014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2024.2306583"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440\u2010024\u201000660\u2010y"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S443177"},{"key":"e_1_2_10_10_1","unstructured":"Centre Hospitalier Universitaire de N\u00eemes Evaluation of the effect of a single dose of psilocybin on neural correlates of cognitive control in patients with psychogenic nonepileptic seizures (CRIPSY) ClinicalTrials.gov. 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